Gabapentin-induced bilateral lower extremity edema in a patient with pervasive developmental disorder and schizoaffective disorder

The Mental Health Clinician
Amber FineganLeigh Anne Nelson

Abstract

Gabapentin binds to the alpha-2-delta subunit of presynaptic voltage-gated calcium channels and is used for a wide variety of on- and off-label indications. Gabapentin is dosed at total daily doses ranging from 300 to 3600 mg/d, which is generally divided into 3 doses. Although gabapentin is generally well tolerated, 1 potential reported adverse effect is peripheral edema. However, due to the extensive number of etiologies of peripheral edema, medication causes may be overlooked on an inpatient psychiatric unit. This is a case of delayed identification of a probable adverse drug reaction to gabapentin (Naranjo score of 5) consisting of painful, 4+ pitting bilateral edema and a clear dose relationship in a patient with pervasive developmental disorder and schizoaffective disorder.

References

Aug 1, 1981·Clinical Pharmacology and Therapeutics·C A NaranjoD J Greenblatt
Aug 27, 2003·The Journal of Clinical Hypertension·Domenic A Sica
Nov 25, 2004·The American Journal of Geriatric Pharmacotherapy·Bruce ParsonsSue Huang
May 10, 2006·Archives of Internal Medicine·David C RadleyRandall S Stafford
Jun 15, 2006·Clinical Neuropharmacology·Mehmet KanbayAli Akcay
Mar 20, 2013·Canadian Pharmacists Journal : CPJ = Revue Des Pharmaciens Du Canada : RPC·Christine FukadaMurray Krahn
Dec 23, 2015·Journal of Basic and Clinical Pharmacy·Arunpreet KahlonDinesh Subedi
Mar 10, 2016·Advanced Biomedical Research·Reza BidakiSeyyed Mohammad Mahdy Mirhosseini
Jun 10, 2017·The Cochrane Database of Systematic Reviews·Philip J WiffenR Andrew Moore

❮ Previous
Next ❯

Citations

Jan 29, 2021·British Journal of Clinical Pharmacology·Bérenger LargeauAnnie-Pierre Jonville-Béra
Mar 16, 2021·Dermatology and Therapy·Shreya A SreekantaswamyDaniel C Butler

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Korean Journal of Ophthalmology : KJO
Ju Young KimYong Sung You
Epilepsy Research. Supplement
M Foot, J Wallace
Epilepsy Research. Supplement
D Chadwick
The Journal of the American Academy of Orthopaedic Surgeons
Richard W Rosenquist
© 2021 Meta ULC. All rights reserved