Gabapentin toxicity in renal failure: the importance of dose adjustment

Pain Medicine : the Official Journal of the American Academy of Pain Medicine
Alice Miller, Grant Price

Abstract

This case report outlines a significant type of morbidity due to continued use of gabapentin during an episode of acute renal failure. Setting. University teaching hospital. Gabapentin is widely used in the management of pain. It is entirely excreted through the renal system so this needs to be considered in any patient becoming acutely ill and developing renal failure. We describe a patient who developed significant deterioration in her conscious level due to iatrogenic gabapentin overdose. All doctors need to be aware of the need to review the indications for gabapentin use during periods of acute illness, especially with regard to renal impairment. Off-label use should be discouraged.

Associated Clinical Trials

Feb 29, 2016·francisco bonofiglio

References

Dec 22, 1999·Therapeutic Drug Monitoring·A VermaR A Radtke
Sep 27, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·N BassiliosJ D Sraer
Jul 3, 2002·Annals of Internal Medicine·Heather JonesHarrison W Farber
Dec 31, 2002·The Annals of Pharmacotherapy·Toni C ButlerGuy W Amsden
Mar 21, 2003·Journal of Toxicology. Clinical Toxicology·Wendy Klein-SchwartzBrad Dahl
Dec 9, 2003·International Journal for Quality in Health Care : Journal of the International Society for Quality in Health Care·William B RuncimanRobert J Adams
Dec 11, 2003·Journal of Managed Care Pharmacy : JMCP·Alicia Mack
Jul 22, 2005·The Cochrane Database of Systematic Reviews·P J WiffenR A Moore
Nov 25, 2005·Pharmacotherapy·Thomas Bookwalter, Matthew Gitlin
Dec 27, 2005·Current Opinion in Pharmacology·Graeme J Sills
Apr 21, 2006·Hemodialysis International·Ayhan DogukanAli I Gunal
Dec 15, 2006·British Journal of Clinical Pharmacology·Marie-Laure LarocheLouis Merle

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Citations

Apr 20, 2011·Nature Reviews. Nephrology·Jamison ChangMitchell H Rosner
Mar 29, 2014·European Journal of Clinical Pharmacology·Eva A SaedderMarianne Lisby
Apr 1, 2010·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Hance ClarkeJoel Katz
Feb 21, 2013·Forensic Science International : Synergy·Ricarda Jantos, Gisela Skopp
Apr 7, 2010·The American Journal of Medicine·Ladan ZandQi Qian
Feb 11, 2015·Epilepsy & Behavior Case Reports·Kenneth R KaufmanMilisha Shah
Mar 20, 2015·Journal of Anaesthesiology, Clinical Pharmacology·Qutaiba A Tawfic, Geoff Bellingham
May 18, 2016·Pain Management·Matthew KohlerPaul D Weyker
Nov 20, 2016·Postgraduate Medicine·Lisa YungRabia S Atayee
Jun 16, 2009·Internal Medicine·Oktay BilgirIsmail Sari
Jan 25, 2019·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Kiran A FaryarGeorge M Bosse
May 28, 2020·International Journal of Dermatology·Terese Monette O AquinoVermen M Verallo-Rowell

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