Gabapentin versus levodopa-c for the treatment of restless legs syndrome in hemodialysis patients: a randomized clinical trial

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
Nazanin RazazianMohammad Rasoul Ghadami

Abstract

To compare the efficacy of gabapentin and levodopa-c (Levodopa/Carbidopa) in reducing restless leg syndrome (RLS) symptoms and sleep problems in hemodialysis patients with RLS in a four-week randomized clinical trial. The diagnosis of RLS was made using the criteria of the International Restless Legs Study Group. Each subject completed three questionnaires: IRLS questionnaire, Pittsburgh Sleep Quality Index and Epworth sleepiness scale. After four weeks of washout period for previous treatments for RLS, subjects were randomly assigned to four weeks of gabapentin (200 mg) or levodopa-c (110 mg). After four weeks of therapy, the questionnaires administered at the outset of the study were re-administered. Both drugs were found effective for the management of RLS. But, the effect of gabapentin was more significant. Gabapentin significantly improved the IRLS total score (change from baseline to post-treatment ≈-17) compared with levodopa-c (change from baseline to post-treatment ≈-13) (P: 0.016). Regarding sleep parameters, levodopa improved sleep quality, sleep latency and sleep duration (P <0.0001). Gabapentin was also effective with respect to sleep parameters (P <0.0001). Our study shows that gabapentin is a safe effective thera...Continue Reading

Citations

Sep 4, 2015·Sleep Medicine Clinics·Denise Sharon
Sep 4, 2015·Sleep Medicine Clinics·Naoko Tachibana
May 25, 2016·Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia·Khichar Shubhakaran
Oct 4, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Jennifer S SchererFrank Brennan
Jan 18, 2018·Metabolic Brain Disease·Maryam MasoudiMohammad Rasoul Ghadami
Nov 8, 2016·The Cochrane Database of Systematic Reviews·Seerapani GopaluniNaim A Ahmadouk
Jun 7, 2018·Journal of the American Society of Nephrology : JASN·Julie H IshidaKirsten L Johansen
Feb 10, 2018·Nephrology·Jin-Lan LiaoMeg Jardine
Jun 4, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Chien-Wei HuangPao-Yen Lin
May 28, 2019·The Cochrane Database of Systematic Reviews·Patrizia NataleGiovanni Fm Strippoli
Aug 20, 2019·Expert Opinion on Pharmacotherapy·Stefano de BiaseMariarosaria Valente
Sep 29, 2018·Substance Abuse : Research and Treatment·Alyssa M PeckhamJordan R Covvey
Apr 22, 2021·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Thomas R GossardErik K St Louis
Oct 7, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jia-Jin ChenChih-Hsiang Chang

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