PMID: 8951214Nov 1, 1996Paper

Gabapentin

The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques
J Bruni

Abstract

Gabapentin is a novel antiepileptic drug that has recently been introduced in Canada. Although its mechanism of action remains to be defined gabapentin is effective in a number of seizure models which predict its efficacy in partial and tonic-clonic seizures. Clinical studies support the clinical efficacy of gabapentin as adjunctive therapy in adults with epilepsy with partial and secondarily generalized tonic-clonic seizures. Gabapentin has a favorable pharmacokinetic profile and is generally well tolerated. More clinical data are required on the role of gabapentin in children and additional monotherapy experience is required before the role of gabapentin in the overall treatment of epilepsy can be better defined.

References

Oct 1, 1996·Epilepsia·A L ReevesL E Krahn

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Citations

Feb 22, 1996·European Journal of Pharmacology·A G KanthasamyD D Truong
Feb 15, 1993·European Journal of Pharmacology·N Suman-ChauhanG N Woodruff
Feb 15, 1993·European Journal of Pharmacology·D R HillG N Woodruff
Nov 30, 2002·Epilepsy Research·Janet L Stringer, Ahmed M Aribi
Apr 9, 2005·Experimental Neurology·Christopher M PetersPatrick W Mantyh
Apr 29, 1998·Current Opinion in Neurology·J W Sander
Apr 17, 2001·The Annals of Pharmacotherapy·L J Miller
Sep 21, 2007·Current Psychiatry Reports·Heather A Berlin
Apr 23, 2002·Anaesthesia·M A Rose, P C A Kam
Jan 22, 2013·Expert Opinion on Drug Metabolism & Toxicology·Alfredo Carlo AltamuraSilvio Bareggi
May 11, 2004·American Journal of Therapeutics·Chadi AlkhalilDavid T Lowenthal

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