Gabexate mesilate, a synthetic protease inhibitor, prevents compression-induced spinal cord injury by inhibiting activation of leukocytes in rats

Critical Care Medicine
Y TaokaK Takatsuki

Abstract

Gabexate mesilate is a synthetic protease inhibitor capable of inhibiting both coagulation and cytokine production by monocytes. To investigate whether gabexate mesilate is useful for the prevention of posttraumatic spinal cord injury, we examined its effect on compression trauma-induced spinal cord injury in rats. Prospective, randomized, blinded, controlled study. Research laboratory at a university medical center. Male Wistar rats weighing 300 to 350 g. Spinal cord injury was induced by applying a 20-g weight extradurally to the spinal cord at the level of the 12th thoracic vertebra for 20 mins. Spinal cord injury was evaluated by assessing the motor function of the rats 24 hrs posttrauma. The accumulation of leukocytes and histologic changes in the injured spinal cord tissue also were examined. Rats received gabexate mesilate (10 or 20 mg/kg i.p.) 30 mins before or after the compressive trauma. The effects of heparin or an inactive derivative of activated factor X (a selective inhibitor of thrombin generation) on compressive trauma-induced spinal cord injury also were examined. Leukocytopenia was induced by the administration of nitrogen mustard. The motor disturbances observed following traumatic spinal cord compression, e...Continue Reading

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Citations

Jun 29, 2013·Brain Research·V KesherwaniS K Agrawal
Oct 14, 1998·Progress in Neurobiology·Y Taoka, K Okajima
Apr 11, 2000·Journal of Neurotrauma·Y Taoka, K Okajima
Dec 23, 2006·Journal of Neurotrauma·Naoaki HaradaKenji Okajima
May 13, 2006·Journal of Neurotrauma·Jason R PotasPhil M E Waite
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Aug 29, 2003·Neurosurgery·Khalaf Al MoutaeryMohammad Tariq
Oct 3, 2006·Current Opinion in Anaesthesiology·T Brüssel

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