GADD45B as a Prognostic and Predictive Biomarker in Stage II Colorectal Cancer

Genes
Zhixun ZhaoXishan Wang

Abstract

GADD45B acts as a member of the growth arrest DNA damage-inducible gene family, which has demonstrated to play critical roles in DNA damage repair, cell growth, and apoptosis. This study aimed to explore the potential relationship between GADD45B expression and tumor progression and evaluate the clinical value of GADD45B in stage II colorectal cancer (CRC). The expression patterns and prognostic value of GADD45B in CRC were analyzed based on The Cancer Genomic Atlas (TCGA). GADD45B expression features of 306 patients with stage II CRC and 201 patients with liver metastasis of CRC were investigated using immunochemical staining on tissue microarrays. Afterward, survival analysis and stratification analysis were performed in stage II to explore the prognostic and predictive significance of GADD45B. Overexpressed GADD45B is associated with poorer prognosis for CRC patients both in overall survival (OS) (p < 0.001) and disease-free survival (DFS) (p = 0.001) based on the TCGA database. Analysis results according to the stage II CRC cohort and the liver metastatic CRC cohort revealed that GADD45B was gradually upregulated in normal mucosa including primary colorectal cancer (PCC). Colorectal liver metastases (CLM) tissues were arran...Continue Reading

References

Sep 16, 2003·Blood Cells, Molecules & Diseases·Dan A Liebermann, Barbara Hoffman
Dec 18, 2007·Lancet·UNKNOWN Quasar Collaborative GroupDavid J Kerr
Jan 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Martin R WeiserW Douglas Wong
Aug 19, 2009·European Journal of Immunology·Songguang JuBinfeng Lu
Nov 1, 2012·Journal of Translational Medicine·Lisha WangXiang Du
Oct 10, 2013·Advances in Experimental Medicine and Biology·Jesús M SalvadorAlbert J Fornace
Mar 5, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dan RosmarinIan Tomlinson
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Sep 23, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Keun-Wook LeeJu-Seog Lee
Apr 15, 2017·Journal of Ovarian Research·Li LiJunjie Zhang
Dec 28, 2017·Cancer Research·Daniela VerzellaGuido Franzoso

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Citations

Oct 5, 2018·International Journal of Molecular Sciences·Gianluca LopezAlessandro Del Gobbo
May 9, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fei MaZhiyong Zhang
Jan 26, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Pankaj AhluwaliaGagandeep K Gahlay
Jul 25, 2021·International Journal of Molecular Sciences·Matthew MartinTao Lu

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Methods Mentioned

BETA
surgical resection

Software Mentioned

SPSS Statistics
R
GEPIA

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