Gadd45b is an epigenetic regulator of juvenile social behavior and alters local pro-inflammatory cytokine production in the rodent amygdala

Brain, Behavior, and Immunity
Stacey L KigarAnthony P Auger

Abstract

Precise regulation of the epigenome during perinatal development is critical to the formation of species-typical behavior later in life. Recent data suggests that Gadd45b facilitates active DNA demethylation by recruiting proteins involved in base excision repair (BER), which will catalyze substitution of 5-methyl-cytosine (5mC) for an unmodified cytosine. While a role for Gadd45b has been implicated in both hippocampal and amygdalar learning tasks, to the best of our knowledge, no study has been done investigating the involvement of Gadd45b in neurodevelopmental programming of social behavior. To address this, we used a targeted siRNA delivery approach to transiently knock down Gadd45b expression in the neonatal rat amygdala. We chose to examine social behavior in the juvenile period, as social deficits associated with neurodevelopmental disorders tend to emerge in humans at an equivalent age. We find that neonatal Gadd45b knock-down results in altered juvenile social behavior and reduced expression of several genes implicated in psychiatric disorders, including methyl-CpG-binding protein 2 (MeCP2), Reelin, and brain derived neurotrophic factor (BDNF). We furthermore report a novel role for Gadd45b in the programmed expression...Continue Reading

References

Jan 1, 1984·Neuroscience and Biobehavioral Reviews·J PankseppL Normansell
Mar 1, 1981·Physiology & Behavior·M J MeaneyW W Beatty
Aug 1, 1997·Progress in Neurobiology·R A Gadient, U H Otten
Nov 10, 2000·Methods : a Companion to Methods in Enzymology·M M McCarthyA M Davis
Dec 24, 2003·Nature Immunology·Binfeng LuRichard A Flavell
Jun 18, 2005·Proceedings of the National Academy of Sciences of the United States of America·Dennis R GraysonErminio Costa
May 9, 2007·Epigenetics : Official Journal of the DNA Methylation Society·Raman P NagarajanJanine M LaSalle
Aug 10, 2007·Blood Cells, Molecules & Diseases·Barbara Hoffman, Dan A Liebermann
Oct 30, 2007·Epigenetics : Official Journal of the DNA Methylation Society·Ko HashimotoHelmtrud I Roach
Nov 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Dag H YasuiJanine M Lasalle
Feb 29, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Louk J M J VanderschurenAnton N M Schoffelmeer
Jul 11, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joseph R KurianAnthony P Auger
Mar 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Catherine J AugerRobin M Forbes-Lorman
Apr 21, 2011·Molecular Pharmacology·Francesco MatriscianoAlessandro Guidotti
Jul 12, 2011·Behavioural Brain Research·Mariana Bendlin CalzavaraVanessa Costhek Abílio
Feb 14, 2012·Biochimica Et Biophysica Acta·Hongen WeiXiaohong Li
Feb 22, 2012·Trends in Cell Biology·Christof Niehrs, Andrea Schäfer
Mar 21, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Robin M Forbes-LormanCatherine J Auger
Jul 18, 2012·Learning & Memory·Prescott T LeachThomas J Gould
Oct 9, 2012·Science·Ja Wook KooEric J Nestler
Dec 1, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Faraz A SultanJ David Sweatt
Jan 19, 2013·Investigative Ophthalmology & Visual Science·Bin LiuYannek I Leiderman
Nov 5, 2013·Brain, Behavior, and Immunity·Michael B HennessyPatricia A Schiml
Nov 26, 2013·Brain Research·Robin M Forbes-LormanAnthony P Auger

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Citations

Apr 19, 2016·Brain Research·Stacey L KigarAnthony P Auger
Oct 31, 2012·Translational Research : the Journal of Laboratory and Clinical Medicine·Katsunori TaiTakanori Ueda
Sep 27, 2016·Hormones and Behavior·Patricia C Lopes
Jan 18, 2017·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Lars Schomacher, Christof Niehrs
Dec 24, 2017·Scientific Reports·Stacey L KigarAnthony P Auger
Mar 16, 2019·Scientific Reports·Benoit LabontéJa Wook Koo
Sep 10, 2020·Frontiers in Behavioral Neuroscience·Karine RoversiJudith R Homberg
Jun 8, 2018·Frontiers in Molecular Neuroscience·Gonca Bayraktar, Michael R Kreutz
Dec 18, 2019·Neuroscience and Biobehavioral Reviews·Chi Him PoonLee Wei Lim
Jan 21, 2021·OncoTargets and Therapy·Lanqing GongXiaoqing Yi
Mar 31, 2021·Biochemical and Biophysical Research Communications·Qingqing YinBin Liu

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