Gadobenate dimeglumine and gadofosveset trisodium for MR angiography of the renal arteries: Multicenter intraindividual crossover comparison

AJR. American Journal of Roentgenology
Guenther SchneiderClaudio Ballarati

Abstract

This prospective multicenter intraindividual crossover study was designed to compare gadobenate dimeglumine and gadofosveset trisodium at approved doses with respect to the image quality and diagnostic performance of contrast-enhanced MR angiography (CE-MRA) in the detection of clinically relevant renal artery stenosis. Thirty-nine subjects (17 men, 22 women; age range, 30-86 years; mean 62 +/- 13.3 [SD] years) with known or suspected renovascular disease underwent a first CE-MRA examination with 0.1 mmol/kg gadobenate dimeglumine and a second examination 3-12 days later with 0.03 mmol/kg gadofosveset. Identical T1-weighted spoiled gradient-refocused echo coronal first-pass images were acquired for 38 of the 39 patients. For 15 of the 38 patients, additional sagittal or axial images or both were acquired with gadofosveset during the steady-state phase. Thirty-four patients underwent digital subtraction angiography, which was the reference standard. Three independent blinded readers assessed source images and maximum-intensity-projection reconstructions to detect clinically relevant (> 50%) renal artery stenosis. Diagnostic performance (sensitivity, specificity, accuracy, positive and negative predictive values) was evaluated wi...Continue Reading

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Citations

May 25, 2013·AJR. American Journal of Roentgenology·Amy Srur SabachRuth P Lim
Jan 22, 2013·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Shenghui XueJenny J Yang
Jul 16, 2011·Journal of Magnetic Resonance Imaging : JMRI·Mike NotohamiprodjoSteven P Sourbron
Apr 11, 2012·Journal of Magnetic Resonance Imaging : JMRI·Laurent MilotCalvin Law
Jun 1, 2010·Topics in Magnetic Resonance Imaging : TMRI·James F M MeaneyPeter Beddy
Mar 14, 2020·AJNR. American Journal of Neuroradiology·J L BeckerK Nael

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