Gadobutrol: A Review in Contrast-Enhanced MRI and MRA

Clinical Drug Investigation
Lesley J Scott

Abstract

Intravenous gadobutrol [Gadovist™ (EU); Gadavist® (USA)] is a second-generation, extracellular non-ionic macrocyclic gadolinium-based contrast agent (GBCA) that is approved for use in paediatric (including term neonates) and adult patients undergoing diagnostic contrast-enhanced (CE) MRI for visualization of pathological lesions in all body regions or for CE MRA to evaluate perfusion and flow-related abnormalities. Its unique physicochemical profile, including its high thermostability and proton relaxation times, means that gadobutrol is formulated at twice the gadolinium ion concentration of other GBCAs, resulting in a narrower bolus and consequently, improved dynamic image enhancement. Based on >  20 years of experience in the clinical trial and real-world settings (>  50 million doses) and its low risk for developing nephrogenic systemic fibrosis (NSF), gadobutrol represents an effective and safe diagnostic GBCA for use in CE MRI and MRA to visualize pathological lesions and vascular perfusion and flow-related abnormalities in all body regions in a broad spectrum of patients, including term neonates and other paediatric patients, young and elderly adult patients, and those with moderate or severe renal or hepatic impairment ...Continue Reading

References

Jan 19, 2000·Investigative Radiology·B TombachW Heindel
Feb 20, 2003·Abdominal Imaging·S K MorcosUNKNOWN European Society of Urogenital Radiology
Aug 21, 2003·European Radiology·Jörn O BalzerRobin Wegener
Oct 19, 2005·Investigative Radiology·Martin RohrerHanns-Joachim Weinmann
Jan 25, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Thomas Grobner
Nov 13, 2008·Investigative Radiology·Thomas FrenzelHanns-Joachim Weinmann
Jul 21, 2009·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Marek MalikPeter Smetana
Oct 28, 2009·Investigative Radiology·Gabriele HahnHans-Joachim Mentzel
May 28, 2010·Arthritis Care & Research·UNKNOWN American College of Rheumatology Musculoskeletal Ultrasound Task Force
May 3, 2011·Advances in Chronic Kidney Disease·Ali K Abu-Alfa
Jul 5, 2011·Journal of the American Academy of Dermatology·Michael GirardiShawn E Cowper
Jun 29, 2012·The British Journal of Radiology·B J HollowayR G Jones
Jul 28, 2013·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·T DurmusT Franiel
Mar 6, 2015·Radiology·Robert J McDonaldLaurence J Eckel
May 23, 2015·AJR. American Journal of Roentgenology·Christian LoeweUNKNOWN DALIA Study Group
Aug 9, 2015·European Radiology·Chan Kyo KimByung Kwan Park
Nov 27, 2015·Japanese Journal of Radiology·Tomonori KandaShigeru Furui
Dec 22, 2015·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Akio TanakaJosy Breuer

❮ Previous
Next ❯

Citations

Sep 14, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Julian GlandorfJens Vogel-Claussen
Nov 9, 2019·Current Drug Metabolism·Mohd Javed AkhtarSalman A Alrokayan
Jun 23, 2020·Annals of Internal Medicine·Joseph LunyeraKaren M Goldstein
Jul 21, 2020·Journal of Biophotonics·Daria K TuchinaValery V Tuchin
Oct 4, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Gabriel RichardMartin Lepage
Jul 16, 2020·BMC Medical Imaging·Markus HenningssonCarl-Johan Carlhäll
Jul 19, 2020·Applied and Environmental Microbiology·Pavel DomninSvetlana Ermolaeva
Jul 13, 2021·Radiology Case Reports·Sudeep AcharyaRabih Maroun
Aug 29, 2021·Journal of Applied Clinical Medical Physics·Jens KüblerRüdiger Hoffmann
Nov 1, 2021·Drug Discovery Today·Jelter Van HoeckKoen Raemdonck

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging techniques
imaging technique

Software Mentioned

GAT
DENSE
UMRI
REMIND
GAD
ME

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Jeffrey G Penfield
Korean Journal of Radiology : Official Journal of the Korean Radiological Society
Jin Woo Choi, Won-Jin Moon
© 2022 Meta ULC. All rights reserved