Gadodiamide and Dentate Nucleus T1 Hyperintensity in Patients With Meningioma Evaluated by Multiple Follow-Up Contrast-Enhanced Magnetic Resonance Examinations With No Systemic Interval Therapy

Investigative Radiology
Carlo Cosimo QuattrocchiBruno Beomonte Zobel

Abstract

The dentate nucleus of the cerebellum may appear as hyperintense on unenhanced T1 magnetic resonance images (MRIs) of the brain. Recently, T1 signal hyperintensity has received attention owing to data on the association of this finding with the history of multiple injections of gadolinium-based contrast agents, specifically gadodiamide, in patients with multiple sclerosis and brain metastases. We conducted a retrospective study on patients with a meningioma who had routinely undergone follow-up enhanced MRI scans with gadodiamide. Across a time interval of 18 months (from January 2013 to July 2014), we identified 102 consecutive patients eligible for this study. A significant increase in T1 hyperintensity of the dentate nuclei of the cerebellum on nonenhanced scans was observed between the first and the last MRI in the group of patients with a history of at least 6 enhanced MRI scans (P < 0.01), whereas no differences were observed in the group with 1 to 5 enhanced MRI scans (P = 0.74). Further research is necessary to shed light on the mechanism of the T1 hyperintensity as well as on the histological and microstructural appearance of the dentate nucleus after multiple intravenous injections of gadodiamide. The finding raises t...Continue Reading

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Citations

Sep 19, 2015·Regulatory Toxicology and Pharmacology : RTP·Hervé GiorgiPhilippe Bourrinet
Jan 27, 2016·Advances in Therapy·Jessica LohrkeHubertus Pietsch
Nov 27, 2015·Japanese Journal of Radiology·Tomonori KandaShigeru Furui
Jan 27, 2016·Journal of the American College of Radiology : JACR·Ashkan A MalayeriDavid A Bluemke
Oct 24, 2015·AJNR. American Journal of Neuroradiology·M E AdinD M Yousem
Dec 27, 2015·La Radiologia medica·Bruno Beomonte ZobelRosario Francesco Grasso
Mar 11, 2016·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Nevzat Karabulut
Mar 19, 2016·Radiology·Scott B Reeder, Vikas Gulani
May 26, 2016·AJR. American Journal of Roentgenology·Richard C SemelkaJoana Ramalho
Dec 15, 2015·AJNR. American Journal of Neuroradiology·J RamalhoM Castillo
Sep 11, 2016·Magnetic Resonance Imaging·Tomonori KandaShigeru Furui
Sep 16, 2016·Magnetic Resonance Imaging·Alexander Radbruch
Oct 4, 2016·Magnetic Resonance Imaging·Joana RamalhoRichard C Semelka
Oct 11, 2016·Magnetic Resonance Imaging·Nozomu MurataKenneth R Maravilla
Dec 23, 2016·Radiology·Carlo Cosimo Quattrocchi, Aart J van der Molen
Apr 1, 2017·La Radiologia medica·Enrico TedeschiArturo Brunetti
Jun 28, 2017·Lancet Neurology·Vikas GulaniUNKNOWN International Society for Magnetic Resonance in Medicine
Apr 1, 2017·The Journal of Vascular Access·Hana Malikova, Michal Holesta

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