Gadolinium accumulation after contrast-enhanced magnetic resonance imaging: Which implications in patients with Crohn's disease?

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Edoardo SavarinoLuca Maria Sconfienza

Abstract

Crohn's disease (CD) is a chronic inflammatory condition of the bowel, characterized by an alternation of remission and relapse phases, leading to a progressive intestinal damage with loss of function. Magnetic resonance enterography has been widely used in the past for the evaluation of fistulizing disease, but its use increased over time, being considered helpful in different moments of disease course. Intravenous injection of Gadolinium-based contrast agents has been demonstrated to be crucial to assess mucosal inflammation, transmural involvement, and extraintestinal disease. Recently, Gadolinium accumulation in human tissues has been increasingly reported, although clinical implications of this event are still unclear. In the present paper, we review the main evidence on the topic, focusing on the potential implications for gastroenterological practice.

Citations

Jul 25, 2017·Expert Review of Gastroenterology & Hepatology·Uri KopylovRami Eliakim
Mar 11, 2018·Clinical Neuroradiology·Richard PullicinoKumar Das
May 22, 2018·Nuclear Medicine Communications·Domenico AlbanoPierpaolo Alongi
Sep 6, 2019·Hematological Oncology·Domenico AlbanoMassimo Galia
Jun 24, 2020·La Radiologia medica·Domenico AlbanoMassimo Galia
Apr 22, 2018·Skeletal Radiology·Domenico AlbanoMassimo Galia
May 20, 2021·La Radiologia medica·Vito ChiancaLuca Maria Sconfienza
Jun 3, 2021·Diagnostics·Domenico AlbanoMassimo Galia
Jun 23, 2021·Diagnostic and Interventional Imaging·Manel DjelouahChristine Hoeffel

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