Gadolinium Augmentation of Myocardial Tissue Heating During Radiofrequency Ablation

JACC. Clinical Electrophysiology
Duy T NguyenWilliam H Sauer

Abstract

This study hypothesized that a metal already commonly used in medical procedures, gadolinium (Gd), will augment radiofrequency (RF) thermal injury and affect cardiac ablation lesions. Enhancement of RF ablation using metallic particles has been proposed for ablation of tumors. A series of ablation lesions were delivered at variable power using an ex vivo model. Tissue temperatures and lesion characteristics were analyzed. Ablation in a porcine in vivo model after direct needle injection of the myocardium with Gd or after systemic administration of Gd encased in heat sensitive liposomes was also performed and compared to control values. Ablation after Gd infiltration of myocardial tissue resulted in significantly larger lesions at both low- and high-power settings. Larger impedance changes were observed during ablation of Gd-treated myocardium. In vivo ablation using a force-sensing irrigated tip catheter resulted in enhanced lesion sizes after Gd injection without a higher incidence of steam pops or perforation. Systemic administration of liposomal Gd with local release by RF heating did not result in larger ablation sizes. Gd can be used to enhance RF ablation lesions. In both ex vivo studies with a 4-mm ablation catheter unde...Continue Reading

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Aug 6, 2014·Journal of Cardiovascular Electrophysiology·Duy T NguyenWilliam H Sauer

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Citations

May 11, 2016·Circulation. Arrhythmia and Electrophysiology·Duy T NguyenWilliam H Sauer
Oct 8, 2019·Journal of Cardiovascular Electrophysiology·Duy T NguyenWilliam H Sauer
Jan 4, 2019·Journal of Cardiovascular Electrophysiology·Duy T NguyenWilliam H Sauer

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