Gadolinium-based contrast agents and their potential role in the pathogenesis of nephrogenic systemic fibrosis: the role of excess ligand

Journal of Magnetic Resonance Imaging : JMRI
M A SieberH Pietsch

Abstract

To investigate the role of excess ligand present in gadolinium (Gd) -based contrast agents in the development of nephrogenic systemic fibrosis (NSF). Using a dosing regimen to simulate the exposure seen in patients with severe renal impairment, we investigated the effect of excess ligand on Gd-deposition and the depletion of endogenous ions. Gadodiamide and gadoversetamide were formulated with 0%, 5%, and 10% excess ligand. Forty-two, healthy, male Hannover Wistar rats received daily intravenous injections of each formulation over a period of 20 days. At the end of the study, histopathological analysis of the skin was performed and the concentrations of Gd, Zn, and Cu were measured in several tissues. The levels of Zn in the urine were also measured. The most severe skin lesions were observed after injection of formulations containing 0% free ligand and in those animals with the highest Gd concentrations in the skin. There were no significant reductions in the levels of Zn or Cu observed in the skin; however, the levels of Zn in the urine were elevated following administration of formulations with the highest amount of excess ligand. Our findings suggest that there is an inverse correlation between the amount of excess ligand p...Continue Reading

References

Jan 1, 1991·Magnetic Resonance Imaging·M F TweedleC A Chang
Jul 24, 2003·The American Journal of Dermatopathology·Shawn E Cowper, Richard Bucala
Jan 10, 2004·Toxicologic Pathology·James W CrissmanDaryl C Thake
Jul 13, 2005·Journal of Cutaneous Pathology·Cynthia KucherRosalie Elenitsas
Aug 18, 2005·Academic Radiology·Val M RungeElissa A Estrada
May 13, 2006·Seminars in Dialysis·Danielle M DeHoratius, Shawn E Cowper
Aug 4, 2006·Journal of the American Society of Nephrology : JASN·Peter MarckmannHenrik S Thomsen
Aug 21, 2007·The British Journal of Radiology·H Schmitt-Willich
Aug 21, 2007·The British Journal of Radiology·M F Tweedle
Aug 23, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·I M WahbaK White

❮ Previous
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Citations

Jun 30, 2009·Investigative Radiology·Narasimharao BhagavathulaJames Varani
Aug 18, 2010·Investigative Radiology·Narasimharao BhagavathulaJames Varani
Sep 23, 2008·AJR. American Journal of Roentgenology·Patrick M Colletti
Apr 23, 2010·AJR. American Journal of Roentgenology·Harald KramerBernd J Wintersperger
Mar 20, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Khaled Abdel-KaderMark L Unruh
Oct 28, 2008·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Li-Juan FuKui Wang
Sep 19, 2015·Regulatory Toxicology and Pharmacology : RTP·Hervé GiorgiPhilippe Bourrinet
Jan 27, 2016·Advances in Therapy·Jessica LohrkeHubertus Pietsch
May 31, 2011·Clinical Biochemistry·Sema YildizMehmet A Eren
Dec 17, 2009·European Journal of Radiology·Hubertus PietschMartin A Sieber
Sep 12, 2009·Radiologic Clinics of North America·Charu Thakral, Jerrold L Abraham
Jan 10, 2009·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·T Steger-HartmannJ Walter
Jul 25, 2009·Journal of Magnetic Resonance Imaging : JMRI·Hubertus PietschMartin A Sieber
Aug 13, 2009·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Zungho ZunKrishna S Nayak
Aug 12, 2009·Congenital Heart Disease·François MarcottePaul Khairy
Nov 26, 2008·Journal of Magnetic Resonance Imaging : JMRI·Christina SchramlFritz Schick
Oct 24, 2012·Journal of Magnetic Resonance Imaging : JMRI·Dapeng HaoMichael Tweedle
May 21, 2011·International Journal of Dermatology·Anna K HaemelArjang Djamali
Nov 26, 2009·Journal of Magnetic Resonance Imaging : JMRI·Martin A SieberHubertus Pietsch
Nov 26, 2009·Journal of Magnetic Resonance Imaging : JMRI·C Leon Partain
Nov 26, 2009·Journal of Magnetic Resonance Imaging : JMRI·Michael MayrGeorg Bongartz
Nov 26, 2009·Journal of Magnetic Resonance Imaging : JMRI·Silvio Aime, Peter Caravan
Sep 27, 2014·Critical Reviews in Toxicology·Jean-Marc IdéeClaire Corot
Mar 5, 2015·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Nathalie FretellierClaire Corot
Sep 9, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Graeme A KeithMatthew D Robson
Jul 3, 2015·Dalton Transactions : an International Journal of Inorganic Chemistry·Bedika PhukanChandan Mukherjee
Dec 24, 2010·World Journal of Radiology·Sameh K Morcos, John Haylor
Jul 12, 2017·Acta Radiologica·Henrik S Thomsen
Sep 30, 2010·Chemical Society Reviews·Meredith A Mintzer, Mark W Grinstaff

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