Gadolinium-based contrast agents induce gadolinium deposits in cerebral vessel walls, while the neuropil is not affected: an autopsy study

Acta Neuropathologica
Stefanie FingerhutUwe Karst

Abstract

Recent studies showed gadolinium depositions following serial administrations of gadolinium-based contrast agents (GBCAs) for magnetic resonance imaging examinations in various parts of the brain with the dentate nucleus (DN) being most affected. Even though no clinical correlates of the deposits are known yet, an intensive debate developed if this might be harmful. The aim of the current study was to specify the gadolinium distribution in brain tissue of patients who received serial injections of GBCAs in the low-µm range and to explore any potential pathological tissue changes caused by gadolinium deposits. Thirteen autopsy cases-eight receiving GBCA administrations, five serving as controls-were identified and analyzed. For all patients, total gadolinium quantification after acidic digestion by means of inductively coupled plasma-mass spectrometry (ICP-MS) was performed. Six cases were utilized for the spatially resolved quantification of gadolinium within the cerebellum and the basal ganglia by means of high-resolution laser ablation (LA)-ICP-MS. Histopathological and immunohistochemical examinations were performed to determine tissue reactions. LA-ICP-MS revealed gadolinium depositions in the walls of small blood vessels o...Continue Reading

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Citations

Jun 2, 2020·Journal of Magnetic Resonance Imaging : JMRI·Carlo A MallioCarlo C Quattrocchi
Apr 5, 2020·Journal of Magnetic Resonance Imaging : JMRI·Marlène RasschaertJean-Marc Idée
Apr 23, 2020·Neuroradiology·Carlo A MallioCarlo C Quattrocchi
May 21, 2020·International Journal of Nanomedicine·Rameshwar PatilEggehard Holler
May 10, 2020·AJNR. American Journal of Neuroradiology·C A MallioP M Parizel
Feb 5, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jing XieEyk Schellenberger
Oct 16, 2020·Seminars in Arthritis and Rheumatism·Sonsoles Piera-VelazquezSergio A Jimenez
Mar 20, 2021·Therapeutic Advances in Neurological Disorders·Diana Lehmann UrbanAngela Rosenbohm
Nov 6, 2020·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Patrick BückerUwe Karst

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