Gadolinium chloride suppresses styrene-induced cytochrome P450s expression in rat liver

Biomedical Research
F HirasawaT Sugiyama

Abstract

To assess the effect of gadolinium (Gd) on the expression of several forms of cytochrome P450 (P450s) and antioxidant enzymes, we treated rats with gadolinium chloride (25 mg as Gd/kg body weight) 4 h after styrene (a multiple P450 inducer) treatment (600 mg/kg). Gd treatment significantly suppressed styrene-inducible cytochrome P4502B1 (CYP2B1), CYP2B2, CYP2E1, and CYP3A2 mRNA expressions to 48.6%, 69.8%, 61.1%, and 38.5%, accompanying with the reduction of proteins expression to 1.42%, 31.2%, 21.1% and 21.1%, respectively, compared with styrene alone treatment. Gd suppressed styrene-inducible CYP1A2 expression, but only at the protein level. On the other hand, styrene treatment caused a decrease in reduced form of glutathione (GSH), as well as increases in lipid peroxide and serum ALT and AST activities, suggesting the occurrence of hepatic damage probably due to styrene-induced oxidative stress in rat liver. Post-treatment of Gd attenuated this styrene-caused hepatic damage. Moreover, mRNA expressions of cellular antioxidant enzymes such as catalase, CuZn-superoxide dismutase (CuZnSOD) and glutathione peroxidase (GPX) were hardly changed by styrene and/or Gd treatment. In summary, Gd suppressed styrene-inducible expression o...Continue Reading

References

Jun 1, 1979·Analytical Biochemistry·H OhkawaK Yagi
Oct 1, 1992·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
Dec 1, 1990·The American Journal of Physiology·A P Bautista, J J Spitzer
Jan 1, 1989·Critical Reviews in Toxicology·J A Bond
Nov 15, 1972·FEBS Letters·M A Symonyan, R M Nalbandyan
Jan 1, 1980·Annual Review of Biochemistry·R E White, M J Coon
Nov 1, 1994·Chemical Research in Toxicology·T NakajimaT Aoyama
Mar 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A P Bautista, J J Spitzer
Jul 1, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S L MichaelJ A Hinson
Sep 22, 2001·Chemico-biological Interactions·P VodickaK Hemminki
Sep 28, 2001·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·P MurielV K Tsutsumi
Dec 8, 2004·Toxicology in Vitro : an International Journal Published in Association with BIBRA·M V VettoriA Mutti
Jan 19, 2006·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·F HirasawaT Sugiyama
May 26, 2006·Proceedings of the National Academy of Sciences of the United States of America·Makoto TeradaKenji Nakanishi

❮ Previous
Next ❯

Citations

Nov 18, 2018·International Journal of Molecular Sciences·Andrés D KleinSilvana Zanlungo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Toxicology and Environmental Health. Part a
Carla CostaJoão Paulo Teixeira
Journal of Occupational and Environmental Medicine
Paolo BoffettaJack S Mandel
International Journal of Hygiene and Environmental Health
Sirilak WongvijitsukMathuros Ruchirawat
© 2021 Meta ULC. All rights reserved