Gadolinium-containing magnetic resonance image contrast agent promotes fibrocyte differentiation.

Journal of Magnetic Resonance Imaging : JMRI
Varsha VakilRichard H Gomer

Abstract

Gadolinium-containing magnetic resonance imaging (MRI) contrast agents such as Omniscan are associated with nephrogenic systemic fibrosis (NSF). To determine if Omniscan can affect the differentiation of monocytes into fibroblast-like cells called fibrocytes that are found in the fibrotic lesions of NSF, peripheral blood mononuclear cells (PBMCs) from NSF patients, hemodialysis patients without NSF, and healthy, renally sufficient controls were exposed to Omniscan in a standardized in vitro fibrocyte differentiation protocol. When added to PBMCs, the gadolinium-containing MRI contrast agent Omniscan generally had little effect on fibrocyte differentiation. However, 10(-8) to 10(-3) mg/mL Omniscan reduced the ability of the fibrocyte differentiation inhibitor serum amyloid P (SAP) to decrease fibrocyte differentiation in PBMCs from 15 of 17 healthy controls and one of three NSF patients. Omniscan reduced the ability of SAP to decrease fibrocyte differentiation from purified monocytes, indicating that the Omniscan effect does not require the presence of other cells (such as T cells) in the PBMCs. Omniscan also reduced the ability of a different fibrocyte differentiation inhibitor, interleukin-12, to decrease fibrocyte differentia...Continue Reading

References

Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·R AbeC N Metz
Oct 20, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·I HartlappC N Metz
Jun 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Matthias SchmidtSabrina Mattoli
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Darrell PillingRichard H Gomer
Jan 25, 2007·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jian Fei WangEdward E Tredget
Jul 4, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Alberto Bellini, Sabrina Mattoli
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Darrell PillingRichard H Gomer
Mar 12, 2008·Journal of Leukocyte Biology·Diane D ShaoDarrell Pilling

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Citations

May 21, 2011·Nature Reviews. Immunology·Ronald A ReilkoffErica L Herzog
May 23, 2012·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Theresa ReiterWolfgang Rudolf Bauer
Jan 12, 2011·Fibrogenesis & Tissue Repair·Ellen C KeeleyRobert M Strieter
May 31, 2011·Clinical Biochemistry·Sema YildizMehmet A Eren
Nov 30, 2010·Seminars in Nuclear Medicine·Emmanuel DurandNicolas Grenier
Mar 23, 2010·Experimental Hematology·Erica L Herzog, Richard Bucala
May 21, 2011·Journal of Cellular and Molecular Medicine·Lorenza BianchettiSabrina Mattoli
Sep 11, 2010·Contrast Media & Molecular Imaging
Nov 26, 2009·Journal of Magnetic Resonance Imaging : JMRI·Tim Leiner, Walter Kucharczyk
Jul 23, 2013·The American Journal of Pathology·Sundararaman SwaminathanKim M Hiatt
Jul 8, 2014·Frontiers in Pharmacology·Charles ReeseStanley Hoffman
Apr 21, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Susan K MathaiErica L Herzog
Jul 12, 2011·British Journal of Pharmacology·N FretellierC Corot
Sep 21, 2012·Journal of Leukocyte Biology·Carole L Galligan, Eleanor N Fish
Jun 1, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter J Wermuth, Sergio A Jimenez
May 21, 2010·Applied Immunohistochemistry & Molecular Morphology : AIMM·Pascale QuatresoozGérald E Piérard

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