Gadolinium deposition and the potential for toxicological sequelae - A literature review of issues surrounding gadolinium-based contrast agents

British Journal of Clinical Pharmacology
Kerry A LayneDavid M Wood

Abstract

Every year, approximately 30 million magnetic resonance imaging scans are enhanced with gadolinium-based contrast agents (GBCAs) worldwide. Although the development of nephrogenic systemic fibrosis in patients with renal impairment is well-documented, over recent years it has become apparent that exposure to GBCAs can potentially result in gadolinium deposition within human bone and brain tissue even in the presence of normal renal function. This review will address some of the controversies surrounding the safety of GBCA administration based on evidence from in vivo experiments, animal studies and clinical studies. We additionally evaluate the potential risk of toxicity from exposure to gadolinium in light of new guidance published by the US Food and Drug Administration and the European Medicines Agency, and discuss whether gadolinium deposition disease exists as a new diagnosis.

References

Jan 1, 1992·Magnetic Resonance Imaging·P WedekingM F Tweedle
Mar 27, 2003·Comprehensive Psychiatry·Thomas D Meyer, Martin Hautzinger
Jul 23, 2003·Archives of Dermatology·William W TingKevin Kurtz
Jan 13, 2004·Lupus·N J AbbottD E M Dolman
Jan 25, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Thomas Grobner
Feb 8, 2006·Seminars in Arthritis and Rheumatism·Fabian A MendozaSergio A Jimenez
Feb 3, 2007·Radiology·Elizabeth A SadowskiArjang Djamali
Aug 22, 2007·Archives of Dermatology·Heather RichmondDavid Fiorentino
Oct 2, 2007·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Henrik S ThomsenVibeke B Logager
Mar 18, 2008·European Journal of Radiology·S K Morcos
Jul 17, 2008·Vascular Health and Risk Management·Mathias Goyen
Sep 23, 2008·AJR. American Journal of Roentgenology·Patrick M Colletti
Nov 13, 2008·Investigative Radiology·Thomas FrenzelHanns-Joachim Weinmann
Nov 26, 2009·Journal of Magnetic Resonance Imaging : JMRI·Silvio Aime, Peter Caravan
Nov 1, 2009·Metallomics : Integrated Biometal Science·Thomas H DarrahRobyn E Hannigan
May 17, 2011·Indian Journal of Dermatology·Rajesh Waikhom, Abhijit Taraphder
May 3, 2012·Radiology·Jae-Woo JungSang-Heon Cho
May 23, 2012·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Theresa ReiterWolfgang Rudolf Bauer
Jun 1, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter J Wermuth, Sergio A Jimenez
Sep 27, 2012·Investigative Radiology·Christiane WackRainer Hofmeister
Oct 11, 2012·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Zhuxian Zhou, Zheng-Rong Lu
Jul 17, 2013·RöFo : Fortschritte auf dem Gebiete der Röntgenstrahlen und der Nuklearmedizin·B VollnbergM Dewey
Aug 13, 2013·Archives of Toxicology·Apostolos ZarrosGeorge S Baillie

❮ Previous
Next ❯

Citations

Feb 7, 2019·Der Radiologe·D Czock
Oct 26, 2018·The International Journal of Cardiovascular Imaging·Amardeep Ghosh DastidarChiara Bucciarelli-Ducci
Mar 30, 2019·The British Journal of Radiology·Samantha J MillsJenkinson Michael D
Nov 9, 2019·Physics in Medicine and Biology·Liqiang RenLifeng Yu
Jan 12, 2020·Emergency Radiology·Kevin HuynhRonald J Zagoria
Oct 31, 2019·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Kerry A LaynePaul I Dargan
Jul 3, 2020·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Ayami Ohno KishimotoKaori Togashi
Sep 3, 2020·AJR. American Journal of Roentgenology·Dogan S PolatBasak E Dogan
May 28, 2020·European Journal of Human Genetics : EJHG·Thierry FrebourgUNKNOWN European Reference Network GENTURIS
Sep 13, 2018·Current Urology Reports·Cara E MorinJonathan R Dillman
Mar 1, 2019·International Journal of Molecular Sciences·Alessandro Fulgenzi, Maria Elena Ferrero
Dec 7, 2019·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Mahan MathurJeffrey C Weinreb
Jan 24, 2020·Contrast Media & Molecular Imaging·Brian C BalesJeannette Roberts
Dec 11, 2019·Contrast Media & Molecular Imaging·Jabadurai Jayapaul, Leif Schröder
Aug 9, 2019·European Radiology Experimental·Renato CuocoloMassimo Imbriaco
Dec 21, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·I PapageorgiouA Malich
Nov 5, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nikolas M DammeKathryn A Morton
Feb 11, 2020·Frontiers in Veterinary Science·J Scott McNallyRonald W Day
Sep 30, 2020·Pharmaceuticals·Pooyan KhalighinejadA Dean Sherry
Aug 1, 2020·Scientific Reports·Ute Lina FahlenkampMarcus Richard Makowski
Sep 3, 2020·Nanomaterials·Sarkar Siddique, James C L Chow
Oct 30, 2020·The Journal of Neuropsychiatry and Clinical Neurosciences·James R BatemanRobin A Hurley
Dec 22, 2020·Computer Methods and Programs in Biomedicine·Annabelle CollinBenjamin Taton
Feb 29, 2020·Clinical Imaging·Mark Lum, A John Tsiouris
Mar 20, 2021·Therapeutic Advances in Neurological Disorders·Diana Lehmann UrbanAngela Rosenbohm
Apr 4, 2021·Journal of Clinical Medicine·Margaret G Keane, Elham Afghani
Apr 7, 2021·Arkhiv patologii·G V PopovV A Varshavsky
Oct 21, 2020·Talanta·Douraied Ben Salem, Jean-Alix Barrat
Apr 25, 2021·European Radiology·Christiane Kulinna-CosentiniEnrico P Cosentini
Apr 5, 2020·Journal of Neuroradiology. Journal De Neuroradiologie·Julien OgnardDouraied Ben Salem
Jul 15, 2021·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Alyson H FitzgeraldSteve Ensley
Aug 13, 2021·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Anabel M Scaranelo
Apr 5, 2021·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Victoria SattarovaCollin M McClelland
Jan 19, 2021·ACS Biomaterials Science & Engineering·Viswanathan HaribabuAgnishwar Girigoswami
May 8, 2020·Inorganic Chemistry·Juan C FríasM Teresa Albelda

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved