Gadolinium-enhanced MR images of the growing piglet skeleton: ionic versus nonionic contrast agent

Radiology
Nina M MenezesDiego Jaramillo

Abstract

To determine whether there are differences in the distribution of ionic and nonionic gadolinium-based contrast agents by evaluating contrast enhancement of the physis, epiphyseal cartilage, secondary ossification center, and metaphysis in the knees of normal piglets. Following approval from the Subcommittee on Research Animal Care, knees of 12 3-week-old piglets were imaged at 3-T magnetic resonance (MR) imaging after intravenous injection of gadoteridol (nonionic contrast agent; n = 6) or gadopentetate dimeglumine (ionic contrast agent; n = 6). Early enhancement evaluation with gradient-echo MR imaging was quantified and compared (Student t test) by means of enhancement ratios. Distribution of contrast material was assessed and compared (Student t test) by means of T1 measurements obtained before and at three 15-minute intervals after contrast agent administration. The relative visibility of the physis, epiphyseal cartilage, secondary ossification center, and metaphysis was qualitatively assessed by two observers and compared (Wilcoxon signed rank test). Differences in matrix content and cellularity that might explain the imaging findings were studied at histologic evaluation. Enhancement ratios were significantly higher for g...Continue Reading

References

Mar 1, 1992·Radiology·B C DangmanE J O'Rourke
May 1, 1972·The Anatomical Record·N J Wilsman, D C Van Sickle
Apr 1, 1996·AJR. American Journal of Roentgenology·D JaramilloF Shapiro
Nov 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A BashirD Burstein
May 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A BashirD Burstein
Jan 9, 2001·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·D BursteinM L Gray
Aug 30, 2001·Radiology·V M Gylys-MorinM H Passo
Jan 17, 2002·The Journal of Bone and Joint Surgery. American Volume·Roberto Rivas, Frederic Shapiro
Jul 20, 2002·Osteoarthritis and Cartilage·E B HunzikerH-J Häuselmann
Dec 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Amy GillisDeborah Burstein
Feb 1, 1960·The Journal of Bone and Joint Surgery. British Volume·J TRUETA, J D MORGAN
Oct 18, 2003·The Journal of Bone and Joint Surgery. American Volume·Young-Jo KimDeborah Burstein
Jan 23, 2004·AJR. American Journal of Roentgenology·Diego JaramilloFrederic Shapiro
Aug 1, 1960·The Journal of Bone and Joint Surgery. British Volume·J Trueta, V P Amato

❮ Previous
Next ❯

Citations

Jul 3, 2008·Pediatric Radiology·Diego Jaramillo
Dec 19, 2008·Radiology·Tal Laor, Diego Jaramillo
Jul 9, 2014·BioMed Research International·Heather Ting MaPing-Chung Leung
Sep 24, 2014·AJR. American Journal of Roentgenology·Maria A BedoyaDiego Jaramillo
Jun 16, 2009·Magnetic Resonance Imaging Clinics of North America·Jerry R Dwek
May 8, 2013·Journal of Magnetic Resonance Imaging : JMRI·Jared Guthrie CobbJohn C Gore
May 1, 2010·Journal of Magnetic Resonance Imaging : JMRI·Heather Ting MaP C Leung
Oct 14, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Gabrielle MartelSheila Laverty
Nov 2, 2013·Acta Radiologica·Peter BoavidaKaren Rosendahl

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.