Gain of antitumor functions and induction of differentiation in cancer stem cells contribute to complete cure and no relapse

Critical Reviews in Oncogenesis
Minal Garg

Abstract

The progeny of the mutated cell is maintained in a self-renewing tissue stem cell and its immediate progeny or due to cellular components that display stem cell like properties known as cancer stem cells (CSCs) that grow into cancer. Failure to achieve complete and safe eradication of cancer is due to the presence of quiescent population of cancer stem cells. Understanding and interfering with the processes of transformation of normal stem cells into their malignant counterparts, their micro-environmental niche and the mechanisms responsible for therapeutic resistance in CSCs enhance the curative efficacy of clinical elimination of all tumor cells. Functional identification of the molecular targets of CSCs provides useful insights for characterization of their response to particular therapy protocols. This review also focuses on the potential implications of promising novel therapies in suppression of oncogenic pathways specific to CSCs including their self-renewal capacity, property of drug transportation, seeding and oxidative stress, activation of apoptosis through the gain of antitumor molecules, restoration of DNA repair mechanisms and differentiation therapy that allows the terminal differentiation of CSCs thereby depleti...Continue Reading

Citations

May 31, 2011·Journal of Translational Medicine·Thomas G P GrunewaldStefan Burdach
Sep 21, 2012·World Journal of Stem Cells·Minal Garg
Aug 10, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Enli LiuQingshan Li

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