Gain-of-Function Genetic Models to Study FSH Action

Frontiers in Endocrinology
Rosemary McDonaldT Rajendra Kumar

Abstract

Follicle-stimulating hormone (FSH) is a pituitary-derived gonadotropin that plays key roles in male and female reproduction. The physiology and biochemistry of FSH have been extensively studied for many years. Beginning in the early 1990s, coincident with advances in the then emerging transgenic animal technology, and continuing till today, several gain-of-function (GOF) models have been developed to understand FSH homeostasis in a physiological context. Our group and others have generated a number of FSH ligand and receptor GOF mouse models. An FSH GOF model when combined with Fshb null mice provides a powerful genetic rescue platform. In this chapter, we discuss different GOF models for FSH synthesis, secretion and action and describe additional novel genetic models that could be developed in the future to further refine the existing models.

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Citations

Mar 20, 2020·Endocrinology·Luisina OngaroDaniel J Bernard
Sep 19, 2020·Biology of Reproduction·Barbara NicolHumphrey H-C Yao
Mar 8, 2020·Animals : an Open Access Journal From MDPI·Wilber Hernández-MontielRoberto Zamora-Bustillos

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Methods Mentioned

BETA
transgenic
targeted mutation
enzyme-linked immunosorbent assay
PCR

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