Jan 8, 2015

Gain of Olig2 function in oligodendrocyte progenitors promotes remyelination

Brain : a Journal of Neurology
Amélie WegenerBrahim Nait-Oumesmar

Abstract

The basic helix-loop-helix transcription factor Olig2 is a key determinant for the specification of neural precursor cells into oligodendrocyte progenitor cells. However, the functional role of Olig2 in oligodendrocyte migration and differentiation remains elusive both during developmental myelination and under demyelinating conditions of the adult central nervous system. To decipher Olig2 functions, we generated transgenic mice (TetOlig2:Sox10(rtTA/+)) overexpressing Olig2 in Sox10(+) oligodendroglial cells in a doxycycline inducible manner. We show that Olig2 overexpression increases the generation of differentiated oligodendrocytes, leading to precocious myelination of the central nervous system. Unexpectedly, we found that gain of Olig2 function in oligodendrocyte progenitor cells enhances their migration rate. To determine whether Olig2 overexpression in adult oligodendrocyte progenitor cells promotes oligodendrocyte regeneration for myelin repair, we induced lysophosphatidylcholine demyelination in the corpus callosum of TetOlig2:Sox10(rtTA/+) and control mice. We found that Olig2 overexpression enhanced oligodendrocyte progenitor cell differentiation and remyelination. To assess the relevance of these findings in demyeli...Continue Reading

Mentioned in this Paper

Doxycycline Phosphate (1: 1)
Doxycycline
Molecular Helix
Myelin Sheath
Remyelination
Helix (Snails)
House mice
Entire Central Nervous System
Myelin
Cell Differentiation Process

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