Gaining Insights from Candida Biofilm Heterogeneity: One Size Does Not Fit All

Journal of Fungi
Ryan KeanGordon Ramage

Abstract

Despite their clinical significance and substantial human health burden, fungal infections remain relatively under-appreciated. The widespread overuse of antibiotics and the increasing requirement for indwelling medical devices provides an opportunistic potential for the overgrowth and colonization of pathogenicCandidaspecies on both biological and inert substrates. Indeed, it is now widely recognized that biofilms are a highly important part of their virulence repertoire.Candida albicansis regarded as the primary fungal biofilm forming species, yet there is also increasing interest and growing body of evidence for non-Candida albicansspecies (NCAS) biofilms, and interkingdom biofilm interactions.C. albicansbiofilms are heterogeneous structures by definition, existing as three-dimensional populations of yeast, pseudo-hyphae, and hyphae, embedded within a self-produced extracellular matrix. Classical molecular approaches, driven by extensive studies of laboratory strains and mutants, have enhanced our knowledge and understanding of how these complex communities develop, thrive, and cause host-mediated damage. Yet our clinical observations tell a different story, with differential patient responses potentially due to inherent bio...Continue Reading

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Citations

Jul 5, 2019·Journal of Medical Microbiology·David RomeraJaime Esteban
Jan 19, 2020·Journal of Fungi·Austin M PerryClarissa J Nobile
Apr 25, 2019·Scientific Reports·Eliandro Reis TavaresSueli Fumie Yamada-Ogatta
Jun 24, 2018·Journal of Fungi·Jeniel E Nett
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Apr 3, 2020·Critical Reviews in Microbiology·Sumaya AbusrewilWilliam McLean
Jan 23, 2021·Critical Reviews in Microbiology·Nicole O PondeJonathan P Richardson
Feb 3, 2021·Critical Reviews in Microbiology·Susana Patrícia LopesMaria Olívia Pereira
Apr 12, 2020·Mycopathologia·Patrícia Pimentel de BarrosJuliana Campos Junqueira
Jan 17, 2020·ACS Applied Materials & Interfaces·Humberto H LaraJose Lopez-Ribot

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