Abstract
Comparative genomic hybridization was used to analyze 41 adult fibrosarcomas from 34 patients. Thirty-one patients showed in their tumors DNA sequence copy number changes (mean 11, range 3-25). The minimal common regions for the most frequent gains were narrowed down to 12q21 (18 cases); 12q14-q15 and 14q22 (16 cases each); 4q22, 7q31, and 14q23-q24 (15 cases each); and 4q21, 4q23-q24, 8q22, and 12q22 (14 cases each). Twenty-five high-level amplifications were observed in 12 samples. 12q21 and 18p were affected three times each; and 1p21, 4q31.3, 7p21, 12q14-q15, Xp22.1-p22.2, and Xq22-q23 two times each. Losses were less frequent than gains. Early stages of adult fibrosarcomas were characterized by frequent gains of chromosomes 2, 4q, and 14q, whereas gains of chromosomes 7 and 8q were associated with progression. Gains of 12q were frequent in all of the developmental steps of this soft-tissue sarcoma. By investigation of several tumors of the same patient, a number of corresponding changes were always detected. Adult fibrosarcomas from patients who died during the observation time showed statistically significant more frequent gains of 8q, 12q, 13q, and 15q compared to the fibrosarcomas of patients who are alive. Gains and hi...Continue Reading
References
Jan 1, 1989·Cancer Genetics and Cytogenetics·N MandahlF Mitelman
Feb 1, 1988·Cancer Genetics and Cytogenetics·N MandahlF Mitelman
Aug 1, 1994·Genes, Chromosomes & Cancer·O P KallioniemiD Pinkel
Apr 1, 1996·Cancer Genetics and Cytogenetics·P Dal CinH Van den Berghe
Jan 1, 1997·The American Journal of Surgical Pathology·T TsujiM Tsuneyoshi
Mar 10, 1998·Genes, Chromosomes & Cancer·J LimonM Debiec-Rychter
Apr 16, 1998·The American Journal of Surgical Pathology·P Dal CinH Van den Berghe
Sep 15, 1998·The American Journal of Pathology·W El-RifaiM Miettinen
Dec 9, 1998·Cancer Genetics and Cytogenetics·D GisselssonN Mandahl
Dec 29, 1998·International Journal of Molecular Medicine·R HinzeH Schmidt
May 29, 1999·Cancer Genetics and Cytogenetics·A MairalA Aurias
Jun 24, 1999·Genes, Chromosomes & Cancer·H SchmidtR Hinze
Dec 22, 1999·Cancer Genetics and Cytogenetics·F ParenteC Turc-Carel
Jan 20, 2000·Cancer Genetics and Cytogenetics·F MertensN Mandahl
Apr 5, 2000·Cancer Genetics and Cytogenetics·A SimonsR Suijkerbuijk
Aug 26, 2000·Cancer Genetics and Cytogenetics·B LevyK Hirschhorn
Apr 18, 2001·International Journal of Cancer. Journal International Du Cancer·F BartelH Taubert
Citations
Jan 28, 2003·Cancer Genetics and Cytogenetics·Valia S LestouDouglas E Horsman
Nov 28, 2006·Nature Reviews. Cancer·Franck Toledo, Geoffrey M Wahl
Dec 7, 2002·Journal of Pediatric Hematology/oncology·Mignon L LohHolcombe E Grier
Apr 14, 2006·Molecular and Cellular Biology·Brad E MorrisonSantosh R D'Mello
Oct 2, 2013·BioMed Research International·Dragana NikitovicGeorge N Tzanakakis
Jul 4, 2012·Cancer Genetics·Anastasios I KyriazoglouNikos Pandis
Jun 8, 2007·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Chueh-Chuan YenJacqueline Whang-Peng
Dec 22, 2005·Molecular Carcinogenesis·Kieran L BransfieldAlan J Mighell
Dec 29, 2006·The Prostate·Amanda K MilesRobert C Rees
Jun 8, 2012·Brain Pathology·Daniela PierscianekHiroko Ohgaki
Mar 20, 2016·Molecular and Cellular Biochemistry·Bhawna RastogiMadhu Khullar
Oct 20, 2009·International Journal of Cancer. Journal International Du Cancer·Ulrike FischerEckart Meese
Oct 12, 2004·Cancer Genetics and Cytogenetics·Wendy T SuWilliam L Gerald
Oct 25, 2016·Cancer Letters·Giuliana CassinelliCinzia Lanzi
Feb 19, 2003·The Journal of Biological Chemistry·Kevin PetrieArthur Zelent
Jan 7, 2010·Journal of Neuro-oncology·Samantha J WardTracy J Warr
Dec 3, 2016·Oncology Letters·Xiaoliang LiuDawei Chen
Dec 18, 2014·World Journal of Gastroenterology : WJG·Niklas GebauerChristoph Thorns
Apr 5, 2005·Cancer Research·Kelly J ReichenbergerHeide L Ford
Jul 1, 2021·Signal Transduction and Targeted Therapy·Victoria DamerellSharon Prince