Gait analysis in PSP and NPH: Dual-task conditions make the difference

Neurology
Charlotte SelgeKlaus Jahn

Abstract

To test whether quantitative gait analysis of gait under single- and dual-task conditions can be used for a differential diagnosis of progressive supranuclear palsy (PSP) and idiopathic normal-pressure hydrocephalus (iNPH). In this cross-sectional study, temporal and spatial gait parameters were analyzed in 38 patients with PSP (Neurological Disorders and Stroke and Society for Progressive Supranuclear Palsy diagnostic criteria), 27 patients with iNPH (international iNPH guidelines), and 38 healthy controls. A pressure-sensitive carpet was used to examine gait under 5 conditions: single task (preferred, slow, and maximal speed), cognitive dual task (walking with serial 7 subtractions), and motor dual task (walking while carrying a tray). The main results were as follows. First, both patients with PSP and those with iNPH exhibited significant gait dysfunction, which was worse in patients with iNPH with a more broad-based gait (p < 0.001). Second, stride time variability was increased in both patient groups, more pronounced in PSP (p = 0.009). Third, cognitive dual task led to a greater reduction of gait velocity in PSP (PSP 34.4% vs iNPH 16.9%, p = 0.002). Motor dual task revealed a dissociation of gait performance: patients wit...Continue Reading

References

Aug 1, 1987·AJR. American Journal of Roentgenology·F FazekasR A Zimmerman
Feb 22, 2001·Journal of Neurology, Neurosurgery, and Psychiatry·H StolzeG Deuschl
Nov 29, 2002·Gerontology·Ginette Azizah MbourouNormand Teasdale
Apr 5, 2007·Brain : a Journal of Neurology·Lawrence I Golbe, Pamela A Ohman-Strickland
Jan 21, 2010·Restorative Neurology and Neuroscience·Klaus Jahn, Andreas Zwergal
Feb 5, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Ulrich LindemannWalter Maetzler
Oct 15, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Roman SchnieppKlaus Jahn
Nov 28, 2012·Journal of Neurology·Nadia K MagdalinouAndrew J Lees
Jan 22, 2013·Journal of Neural Transmission·Paulo BugalhoRita Miguel
Nov 1, 2013·Neurology. Clinical Practice·Michael A Williams, Norman R Relkin
Jun 26, 2014·Seminars in Neurology·Lawrence I Golbe
Aug 16, 2014·Journal of Parkinson's Disease·Jorik NonnekesBastiaan R Bloem
Nov 6, 2014·Movement Disorders : Official Journal of the Movement Disorder Society·Gesine RespondekUNKNOWN Movement Disorder Society-endorsed PSP Study Group
Jun 3, 2015·Parkinsonism & Related Disorders·Shinichi AmanoChris J Hass
Jan 1, 2014·Journal of Clinical Movement Disorders·Brian W StarrAlberto J Espay
Jun 12, 2016·European Neurology·Noriko HatanakaKoji Abe
Oct 23, 2016·Wiener klinische Wochenschrift·Walter Pirker, Regina Katzenschlager
Nov 29, 2016·Nature Neuroscience·Daniel JustusStefan Remy

❮ Previous
Next ❯

Citations

Jun 5, 2019·Zeitschrift für Gerontologie und Geriatrie·Klaus JahnJochen Klucken
May 23, 2020·Physiological Measurement·Tomas BäcklundNina Sundström
Jul 4, 2020·Journal of Motor Behavior·Jessica PreborSteven Morrison
Apr 20, 2019·Frontiers in Neurology·Marianne Dieterich, Thomas Brandt
Mar 24, 2021·Acta Neurologica Scandinavica·Yasutaka NikaidoRyuichi Saura
Apr 28, 2021·Clinical Neurology and Neurosurgery·Ryo OikeTakatoshi Sorimachi
Oct 12, 2021·Acta Neurologica Scandinavica·Yasutaka NikaidoRyuichi Saura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved