Gait deviations in Duchenne muscular dystrophy-Part 2. Statistical non-parametric mapping to analyze gait deviations in children with Duchenne muscular dystrophy

Gait & Posture
Marije GoudriaanKaat Desloovere

Abstract

Prolonged ambulation is considered important in children with Duchenne muscular dystrophy (DMD). However, previous studies analyzing DMD gait were sensitive to false positive outcomes, caused by uncorrected multiple comparisons, regional focus bias, and inter-component covariance bias. Also, while muscle weakness is often suggested to be the main cause for the altered gait pattern in DMD, this was never verified. Our research question was twofold: 1) are we able to confirm the sagittal kinematic and kinetic gait alterations described in a previous review with statistical non-parametric mapping (SnPM)? And 2) are these gait deviations related to lower limb weakness? We compared gait kinematics and kinetics of 15 children with DMD and 15 typical developing (TD) children (5-17 years), with a two sample Hotelling's T2 test and post-hoc two-tailed, two-sample t-test. We used canonical correlation analyses to study the relationship between weakness and altered gait parameters. For all analyses, α-level was corrected for multiple comparisons, resulting in α = 0.005. We only found one of the previously reported kinematic deviations: the children with DMD had an increased knee flexion angle during swing (p = 0.0006). Observed gait devia...Continue Reading

Citations

Jun 21, 2018·Glycobiology·Laurino CarmenTommaso Iannitti
Dec 31, 2019·Applied Bionics and Biomechanics·Slawomir WiniarskiKrzysztof Aleksandrowicz
Jan 14, 2020·Journal of Biomechanics·Enrica PapiAlison H McGregor
Sep 4, 2020·Journal of Applied Physiology·Katherine E BukovecRobert W Grange
Sep 24, 2021·Pflügers Archiv : European journal of physiology·Kay Ohlendieck, Dieter Swandulla
Dec 4, 2019·Neuromuscular Disorders : NMD·Alberto RomanoGessica Vasco

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