DOI: 10.1101/19000166Jun 25, 2019Paper

Gait differences in patients with multiple sclerosis who have low and high levels of disability.

MedRxiv : the Preprint Server for Health Sciences
John J Fraser, Jeannie Stephensen


Background: Multiple Sclerosis (MS) often results in gait impairment and disability. Objective: To investigate differences in spatiotemporal gait characteristics of people with MS who have low versus high levels of disability. Between trial and inter-limb consistency and the association of gait variables with level of disability were also investigated. Methods: Participants with MS who had either low-disability [n=7; 3 females; EDSS mean: 2.7{+/-}0.5, range 2.0-4.5; BMI=26.9{+/-}6.6] or high-disability [n=11; 6 females; EDSS mean: 2.7{+/-}0.5, range 6.0-6.5; BMI=27.8{+/-}1.5) performed 2 trials of self-selected walking on an instrumented walkway. Differences in group, limb, and group by limb interactions were assessed using analysis of variance, independent-measures t-tests, and Cohen's d effect sizes (ES). Between-trial consistency of gait were assessed with intra-class correlation coefficients (2, k). Results: Participants in the high disability group had increased step time (ES=0.8), cycle time (ES=0.8), and ambulation time (ES=1.2) while taking shorter strides (ES=0.9) and more steps at a slower rate (ES=1.1). The high disability group demonstrated less between-trial consistency for 69% of gait variables when compared to th...Continue Reading

Software Mentioned

GAITRite Walkway
Statistical Package for Social Sciences

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