DOI: 10.1101/19000166Jun 25, 2019Paper

Gait differences in patients with multiple sclerosis who have low and high levels of disability.

MedRxiv : the Preprint Server for Health Sciences
John J Fraser, Jeannie Stephensen

Abstract

Background: Multiple Sclerosis (MS) often results in gait impairment and disability. Objective: To investigate differences in spatiotemporal gait characteristics of people with MS who have low versus high levels of disability. Between trial and inter-limb consistency and the association of gait variables with level of disability were also investigated. Methods: Participants with MS who had either low-disability [n=7; 3 females; EDSS mean: 2.7{+/-}0.5, range 2.0-4.5; BMI=26.9{+/-}6.6] or high-disability [n=11; 6 females; EDSS mean: 2.7{+/-}0.5, range 6.0-6.5; BMI=27.8{+/-}1.5) performed 2 trials of self-selected walking on an instrumented walkway. Differences in group, limb, and group by limb interactions were assessed using analysis of variance, independent-measures t-tests, and Cohen's d effect sizes (ES). Between-trial consistency of gait were assessed with intra-class correlation coefficients (2, k). Results: Participants in the high disability group had increased step time (ES=0.8), cycle time (ES=0.8), and ambulation time (ES=1.2) while taking shorter strides (ES=0.9) and more steps at a slower rate (ES=1.1). The high disability group demonstrated less between-trial consistency for 69% of gait variables when compared to th...Continue Reading

Software Mentioned

GAITRite Walkway
GAITRite
Statistical Package for Social Sciences

Related Concepts

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.