Gait Speed and the Natural Course of Depressive Symptoms in Late Life; An Independent Association With Chronicity?

Journal of the American Medical Directors Association
Joost B SandersAartjan T F Beekman

Abstract

Psychomotor slowing is a core feature of depression in late life, but its prognostic value with respect to course and chronicity is unclear. We investigated whether gait speed can predict chronicity of depressive symptoms. Furthermore, we tested whether (1) cognitive slowing and (risk factors for) vascular diseases, (2) a marker of chronic inflammation, and (3) specific somatic conditions could explain this association. In the population-based Longitudinal Aging Study Amsterdam, 271 aged participants with clinically relevant depressive symptoms (Center for Epidemiologic Studies Depression Scale ≥16) were followed during a period of 6 years. With 14 successive Center for Epidemiologic Studies Depression Scale observations, 3 clinical course types of depressive symptoms were defined. Remission, fluctuating course, and chronic course of depressive symptoms were seen in 21%, 48%, and 30%, respectively. Slowed gait speed at baseline was associated with a chronic course of depressive symptoms using remission as the reference (odds ratio 0.56, 95% confidence interval 0.41-0.77). Processing speed and vascular risk factors explained this association only for 2%. Specific somatic comorbidity (number of chronic diseases, chronic obstructi...Continue Reading

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Citations

May 29, 2016·Journal of the American Medical Directors Association·John E Morley
Sep 7, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Eric J LenzeSteven P Roose
Feb 15, 2017·International Journal of Geriatric Psychiatry·Nicola VeroneseBrendon Stubbs
Jan 3, 2018·International Journal of Geriatric Psychiatry·Gilles AllaliFrédéric Assal
Feb 7, 2019·Journal of the American Geriatrics Society·Robert BriggsRose Anne Kenny
May 30, 2020·Journal of Psychiatry and Brain Science·Stewart A ShankmanSebastian Walther
Feb 9, 2021·Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition·Mehmet Ilkin NaharciIlker Tasci
Feb 14, 2021·International Journal of Environmental Research and Public Health·Leonardo ZoccanteMarco Colizzi
Jan 31, 2020·Ageing Research Reviews·Richard D SembaLuigi Ferrucci
Sep 11, 2021·Journal of Neurologic Physical Therapy : JNPT·Susannah Julie FlugonGro Gujord Tangen

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