Gait variability across the disability spectrum in people with multiple sclerosis

Journal of the Neurological Sciences
Alon Kalron

Abstract

An alternative method suggested to assess changes in walking in people with multiple sclerosis (PwMS) is evaluating gait variability. This is a credible option since gait variability reflects to some degree the quality of gait control. Examine the impact of disability on gait variability in PwMS. In this cross-sectional study, the data pool was divided into seven levels of disability based on the Expanded Disability Status Scale (EDSS) score, ranging from 0 to 6.5. Gait variability was studied using an electronic mat. The final analysis included 381 PwMS (249 women); mean age 44.0years. Non-significant differences were observed between the EDSS subgroups at the lower end of the spectrum (EDSS 0-3.5) in all gait variability parameters. In contrast, PwMS in the EDSS 5.0-5.5 group demonstrated a significant increase in variability of step length (~151%), single support (~93%) and step time (142%) compared with those who scored 0-3.5. Moreover, participants in the EDSS 5.0-5.5 group had elevated step length variability compared to the EDSS 4.0-4.5 group (9.3 (S.E.=2.2) vs. 5.5 (S.E.=0.4), P-value=0.005). We encourage clinicians to follow-up on the gait variability score as it appears to reflect mobility deterioration in PwMS.

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Citations

May 29, 2018·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·A KalronA Achiron
Sep 6, 2019·Current Neurology and Neuroscience Reports·Mikaela L FrechetteJacob J Sosnoff
Dec 23, 2016·Frontiers in Human Neuroscience·John M BardenOlivier Beauchet
Feb 6, 2019·Frontiers in Aging Neuroscience·Daniel KronebergTanja Schmitz-Hübsch
Jan 19, 2021·Archives of Physical Medicine and Rehabilitation·Justin N CheeKara K Patterson
Aug 10, 2021·Journal of Neurologic Physical Therapy : JNPT·Shirley HandelzaltsItshak Melzer

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