Galacto-Oligosaccharide/Polidextrose Enriched Formula Protects against Respiratory Infections in Infants at High Risk of Atopy: A Randomized Clinical Trial

Nutrients
Giusy RanucciAlfredo Guarino

Abstract

Early nutrition affects the risk of atopy and infections through modifications of intestinal microbiota. The Prebiotics in the Prevention of Atopy (PIPA) study was a 24-month randomised, double-blind, placebo-controlled trial. It aimed to evaluate the effects of a galacto-oligosaccharide/polydextrose (GOS/PDX)-formula (PF) on atopic dermatitis (AD) and common infections in infants who were born to atopic parents and to investigate the relationship among early nutrition, gut microbiota and clinical outcomes. A total of 201 and 199 infants were randomized to receive a PF and standard formula (SF), respectively; 140 infants remained on exclusive breastfeeding (BF). The cumulative incidence of AD and its intensity and duration were not statistically different among the three groups. The number of infants with at least one episode of respiratory infection (RI) and the mean number of episodes until 48 weeks of age were significantly lower in the PF group than in the SF group. The number of patients with recurrent RIs and incidence of wheezing lower RIs until 96 weeks were lower in the PF group than the SF group, but similar to the BF group. Bifidobacteria and Clostridium cluster I colonization increased over time in the PF group but ...Continue Reading

Associated Clinical Trials

Apr 16, 2014·Alfredo Guarino

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Citations

Jul 7, 2020·EFSA Journal·UNKNOWN EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA)Dominique Turck
Sep 27, 2018·Frontiers in Pediatrics·Veronica Ayechu-MuruzabalBelinda Van't Land
Aug 11, 2019·Nutrients·Carole BrosseauMarie Bodinier
Mar 12, 2020·Frontiers in Microbiology·Dapeng ZhangYibin Feng
Jan 9, 2021·Frontiers in Pediatrics·Simona SestitoLicia Pensabene
Mar 16, 2021·Frontiers in Immunology·Mandy PierauMonika C Brunner-Weinzierl
Oct 21, 2021·Nutrition Research Reviews·Kamila Sabino BatistaJailane de Souza Aquino

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Clinical Trials Mentioned

NCT02116452

Software Mentioned

Pedianet
NIS
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Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.