Galactose induces in Saccharomyces cerevisiae sensitivity of the utilization of hexoses to inhibition by D-glucosamine

Canadian Journal of Microbiology
J Nevado, C F Heredia

Abstract

Inhibition by glucosamine of the utilization of hexoses by Saccharomyces cerevisiae is induced by growing the cells in media with galactose as carbon source. The intensity of inhibition parallels the induction of the galactose pathway. These findings contrast with the fact that glucosamine is a substrate of the constitutive glucose but not of the inducible. galactose transport and phosphorylation systems. The inhibition by glucosamine is pH dependent; the extent seems to be related with phosphorylation of the hexosamine, as shown by its greater effect with substrates or with conditions that less interfere with the phosphorylation of the inhibitor. Inhibition is not a consequence of ATP depletion of the cell. Intracellular accumulated glucosamine derivatives impair the transport of glucose and mannose in yeast cells grown in galactose-supplemented media but not those grown with glucose or ethanol supplements (i.e., under conditions in which the utilization of these sugars is inhibited). However, impairment of the transport is not enough to explain the characteristics of the observed inhibition. The changes induced by growing the yeast in galactose that render the cells sensitive to glucosamine are under the control of the gal80 ...Continue Reading

References

Oct 24, 1977·Molecular & General Genetics : MGG·A Furst, C A Michels
Sep 1, 1989·Journal of General Microbiology·E M McGoldrick, A E Wheals
Aug 1, 1968·European Journal of Biochemistry·C F HerediaG DelaFuente
Oct 1, 1958·Biochimica Et Biophysica Acta·A SOLSC ASENSIO
Jul 1, 1960·Biochimica Et Biophysica Acta·F ALVARADO
May 11, 1964·Biochimica Et Biophysica Acta·C F HEREDIA, A SOLS

❮ Previous
Next ❯

Citations

Oct 3, 2009·Genes & Development·Jessica C S Brown, Susan Lindquist
Sep 30, 2000·Applied and Environmental Microbiology·P LuceroR Lagunas
Dec 8, 2015·Applied and Environmental Microbiology·Xinping XuXiaorong Lin
Aug 1, 1997·FEMS Microbiology Reviews·E Boles, C P Hollenberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.