Galactose inhibition of the constitutive transport of hexoses in Saccharomyces cerevisiae

Yeast
J NevadoC F Heredia

Abstract

The relationship between the pathways of glucose and galactose utilization in Saccharomyces cerevisiae has been studied. Galactose (which is transported and phosphorylated by inducible systems) is a strong inhibitor of the utilization of glucose, fructose and mannose (which have the same constitutive transport and phosphorylation systems). Conversely, all these three hexoses inhibit the utilization of galactose, though with poor efficiency. These cross-inhibitions only occur in yeast adapted to galactose or in galactose-constitutive mutants. The efficiency of galactose as inhibitor is even greater than the efficiencies of the other three hexoses to inhibit the utilization of each other. Phosphorylation is not involved in the inhibition and the transport of sugars is the affected step. The cross-inhibitions between galactose and either glucose, fructose or mannose do not implicate utilization of one hexose at the expense of the other, as it occurs in the mutual interactions between the latter three sugars. It seems that, by growing the yeast in galactose, a protein component is synthesized, or alternatively modified, that once bound to either galactose or any one of the other three hexoses (glucose, fructose or mannose), cross-i...Continue Reading

References

Jan 1, 1975·Folia Microbiologica·A KotykV Soukupová
Oct 1, 1971·Journal of Bacteriology·J Bassel, R Mortimer
Aug 1, 1968·European Journal of Biochemistry·C F HerediaG DelaFuente
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·L F Bisson, D G Fraenkel
Sep 1, 1983·Journal of Bacteriology·L F Bisson, D G Fraenkel
Dec 1, 1954·Journal of Bacteriology·H C DOUGLAS, F CONDIE
Oct 1, 1958·Biochimica Et Biophysica Acta·A SOLSC ASENSIO
Jul 1, 1960·Biochimica Et Biophysica Acta·F ALVARADO
May 11, 1964·Biochimica Et Biophysica Acta·C F HEREDIA, A SOLS

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Citations

Feb 14, 2006·Biotechnology and Bioengineering·Jeffrey D KeatingShawn D Mansfield
Jul 15, 2004·Journal of Industrial Microbiology & Biotechnology·J D KeatingS D Mansfield
May 2, 2014·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Stephen C MitchellRobert L Smith
Jan 6, 2011·Critical Reviews in Biotechnology·Anjali MadhavanVirendra S Bisaria
Aug 1, 1997·FEMS Microbiology Reviews·E Boles, C P Hollenberg
Nov 14, 1998·Biochimica Et Biophysica Acta·C F Heredia
Sep 8, 1999·Microbiology and Molecular Biology Reviews : MMBR·S Ozcan, M Johnston

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