Galactosyltransferase isoenzyme II in the detection of pancreatic cancer: comparison with radiologic, endoscopic, and serologic tests

The New England Journal of Medicine
D K PodolskyK J Isselbacher

Abstract

We assessed the value of several serologic markers in detecting pancreatic carcinoma in a prospective study of 270 patients. The sensitivity and specificity of galactosyltransferase isoenzyme II (GT-II), carcinoembryonic antigen (CEA), alpha-fetoprotein, ferritin, C1q binding, and ribonuclease were determined. GT-II was the most sensitive (67.2 per cent) and specific (98.2 per cent) for discriminating between benign and malignant disease and was more sensitive and specific than CEA, the next most useful marker. Sensitivity was 64 per cent for ultrasound, 79.4 per cent for computerized body tomography (CBT), and 92.8 per cent for endoscopic retrograde cholangiopancreatography (ERCP). As a single test, only ERCP was more sensitive than GT-II, but more sensitive diagnoses resulted when GT-II was combined with ultrasound (92 per cent), CBT (88 per cent), or ERCP (100 per cent). Serum GT-II may be useful both by itself and in combination with imaging techniques in distinguishing benign from malignant pancreatic disease; however, this test does not discriminate between pancreatic carcinoma and other gastrointestinal neoplasms.

References

Aug 30, 1979·The New England Journal of Medicine·R E Hermann, A M Cooperman
Dec 1, 1979·American Journal of Surgery·K ReedB S Jarstfer
Jul 22, 1975·Biochemical and Biophysical Research Communications·D K Podolsky, M M Weiser
Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·L M Peterson
Feb 1, 1979·Annals of Surgery·J F Forrest, W P Longmire
Mar 1, 1979·Annals of Surgery·R L GoodaleK Gajl-Peczalska
Mar 1, 1978·Cancer·P J FitzgeraldM H Poleski
Jun 1, 1978·Journal of the National Cancer Institute·A A Mihas
Sep 28, 1978·The New England Journal of Medicine·D K PodolskyA M Cohen
Oct 6, 1977·The New England Journal of Medicine·E P DiMagnoV L Go
Apr 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·M M WeiserK J Iselbacher
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·K K Reddi, J F Holland
Mar 1, 1975·The Medical Clinics of North America·M Garabedian, M Shamszad
Aug 1, 1974·Radiology·H M GoldsteinJ J Bookstein
May 1, 1970·Gut·G Engelhart, U W Blauenstein
Jan 1, 1971·The American Journal of Digestive Diseases·T L MooreN Zamcheck
Oct 1, 1969·Radiology·J J BooksteinW Martel
Jan 1, 1980·American Journal of Surgery·A L WarshawA M Cohen

❮ Previous
Next ❯

Citations

Dec 1, 1984·World Journal of Surgery·L Gordis, E B Gold
Dec 1, 1984·World Journal of Surgery·D K Podolsky
Dec 1, 1984·World Journal of Surgery·M D SilversteinA L Warshaw
Dec 1, 1996·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·F SafiH G Beger
Dec 24, 1981·Clinica Chimica Acta; International Journal of Clinical Chemistry·R LoorT M Chu
Sep 15, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·T P CorbishleyR Williams
Feb 1, 1993·Molecular Immunology·M TomanaJ Mestecky
Dec 1, 1990·Baillière's Clinical Gastroenterology·J M Rhodes, C K Ching
Sep 24, 1981·The New England Journal of Medicine
Feb 13, 1992·The New England Journal of Medicine·A L Warshaw, C Fernández-del Castillo
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·D K Podolsky, K J Isselbacher
Feb 6, 1982·British Medical Journal·M A Benarde, W Weiss
Sep 1, 1985·Cancer Treatment Reviews·S E Bates, D L Longo
Apr 1, 1985·European Journal of Cancer & Clinical Oncology·R FariniR Naccarato
Jul 30, 2002·Gastrointestinal Endoscopy·J Shawn MalleryWilliam R Brugge
Jan 1, 1985·CRC Critical Reviews in Biochemistry·B P Ram, D D Munjal
Feb 15, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·F A BoyleT J Peters
Jan 1, 1993·Critical Reviews in Clinical Laboratory Sciences·I Brockhausen
Jan 1, 1988·Gastrointestinal Endoscopy·A R KaufmanD R Ferguson
Apr 1, 1987·Medical Decision Making : an International Journal of the Society for Medical Decision Making·D L SimelD B Matchar
Apr 15, 1986·Cancer·G Del FaveroR Naccarato
Mar 12, 1993·International Journal of Cancer. Journal International Du Cancer·H FriessH G Beger
May 1, 1988·International Journal of Pancreatology : Official Journal of the International Association of Pancreatology·E J BoydK G Wormsley
Mar 30, 1982·Biochemical and Biophysical Research Communications·J R WilsonE G Berger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The New England Journal of Medicine
D K PodolskyA M Cohen
Biochemical and Biophysical Research Communications
J R WilsonE G Berger
Proceedings of the National Academy of Sciences of the United States of America
M M WeiserK J Iselbacher
© 2021 Meta ULC. All rights reserved