Galangin (3,5,7-trihydroxyflavone) shields human keratinocytes from ultraviolet B-induced oxidative stress

Biomolecules & Therapeutics
Susara Ruwan Kumara Madduma HewageJin Won Hyun

Abstract

Most skin damage caused by ultraviolet B (UVB) radiation is owing to the generation of reactive oxygen species. Phytochemicals can act as antioxidants against UVB-induced oxidative stress. This study investigated the protective effects of the flavone galangin against UVB-induced oxidative damage in human keratinocytes. Galangin efficiently scavenged free radicals and reduced UVB-induced damage to cellular macromolecules, such as DNA, lipids, and proteins. Furthermore, galangin rescued cells undergoing apoptosis induced by UVB radiation via recovering mitochondrial polarization and down-regulating apoptotic proteins. These results showed that galangin protects human keratinocytes against UVB radiation-induced cellular damage and apoptosis via its antioxidant effects.

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Citations

Mar 19, 2016·Environmental Toxicology and Pharmacology·Pattage Madushan Dilhara Jayatissa FernandoJin Won Hyun
Nov 11, 2016·Biomolecules & Therapeutics·Susara Ruwan Kumara Madduma HewageJin Won Hyun
Aug 24, 2017·Environmental Toxicology·Su-Ying WenWei-Wen Kuo
Jan 6, 2016·Molecular and Cellular Biochemistry·Yifan ZhangQingfeng Li
Jan 10, 2018·Biological & Pharmaceutical Bulletin·Ki Wung ChungHyung Ryong Moon

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Methods Mentioned

BETA
ESR
electrophoresis
ELISA
flow cytometry

Software Mentioned

Laser Scanning Microscope 5 PASCAL

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis