PMID: 7541102Jan 1, 1995Paper

Galanin and somatostatin inhibition of neurokinin A and B induced airway mucus secretion in the rat

Life Sciences
U WagnerP von Wichert

Abstract

Neurokinin A and B are present in neurons situated in lung and NK-1 receptors have been described on tracheal submucosal gland cells. In the present study we compared the ability of substance P (SP), neurokinin A (NKA) and neurokinin B (NKB) to stimulate airway mucus secretion. Furthermore, we characterized the interaction of NKA and NKB with galanin and somatostatin. The rank order of the tachykinins to stimulate airway mucus secretion was SP > NKA > NKB suggesting that NK-1 receptors mediate these effects(EC50:SP: 50 nmol/l, NKA: 200 nmol/l, NKB: 400 nmol/l). Galanin and somatostatin were equally potent to inhibit NK-A and NK-B stimulated airway mucus release. These results suggest that NK-A and NK-B are potent stimulators of airway macromolecule secretion. Galanin and somatostatin potently inhibit these actions of the tachykinins. Therefore, airway mucus secretion is controlled by a complex network of several different mediators.

References

Jun 1, 1992·Journal of Neurochemistry·S Rens-Domiano, T Reisine
Jun 1, 1992·Pulmonary Pharmacology·J D Lundgren, J N Baraniuk
May 1, 1992·Experimental Lung Research·L A Cohn, K B Adler
Jul 1, 1991·The Journal of Allergy and Clinical Immunology·T B Casale
Jan 1, 1991·Respiration; International Review of Thoracic Diseases·U Wagner, P von Wichert
Apr 1, 1987·Journal of Applied Physiology·R W FullerP J Barnes
Dec 1, 1987·The American Review of Respiratory Disease·P S Richardson, S E Webber
Aug 15, 1986·European Journal of Pharmacology·J R Castairs, P J Barnes
Aug 1, 1985·The Journal of Physiology·B BakerP S Richardson
Nov 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·S J ColesL M Reid
Jan 1, 1993·Trends in Neurosciences·G I Bell, T Reisine
Jan 1, 1993·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·U WagnerB Göke
Jul 2, 1993·Regulatory Peptides·S NakanishiY Yokota
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·L RohrerR Schüle

❮ Previous
Next ❯

Citations

Jan 1, 1995·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·U WagnerP von Wichert
Feb 13, 2001·European Journal of Pharmacology·D BredenbrökerU Wagner
Mar 26, 2002·Molecular and Cellular Endocrinology·Stephan PetersennH M Schulte
Jul 1, 1997·British Journal of Pharmacology·J SchloosC Bruns
Jan 11, 2003·British Journal of Pharmacology·Jonathan E PhillipsMichel R Corboz
Jun 9, 2006·Journal of Occupational Medicine and Toxicology·Ulrich WagnerDavid A Groneberg
Feb 22, 2008·Journal of Occupational Medicine and Toxicology·Rene SchmidtUlrich Wagner
Sep 4, 2015·Physiological Reviews·Jonathan H Widdicombe, Jeffrey J Wine

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.