Galanin and somatostatin inhibition of substance P-induced airway mucus secretion in the rat

Neuropeptides
U WagnerP Von Wichert

Abstract

Substance P is present in several neurons innervating the lung. Tachykinin receptors are expressed on submucosal gland cells. Substance P is known to be a potent stimulator of airway mucus secretion. In the present study we characterized the effects of galanin and somatostatin on basal and substance P-induced mucus secretion. The stimulatory effect of substance P was concentration-dependent (100 pmol/l: 112%, 1 nmol/l: 120%, 10 nmol/l: 153%, 100 nmol/l: 223%, 1 mumol/l: 275%, 10 mumol/l: 172%) and was inhibited by galanin and somatostatin (1 mumol/l substance P: 277%; 1 mumol/l substance P + 1 mumol/l somatostatin: 190%, p < 0.01; 1 mumol/l substance P + 1 mumol/l galanin: 206%, p < 0.05). In the presence of lower concentrations of substance P 1 mumol/l somatostatin and 1 mumol/l galanin did not modify mucus secretion. Lower concentrations of galanin and somatostatin did not significantly change mucus secretion stimulated by 1 mumol/l substance P. Both, galanin and somatostatin at 1 mumol/l left basal airway mucus secretion unaltered. These data suggest that mucus secretion into airways is regulated by a complex network of peptidergic stimulators and inhibitors including substance P, somatostatin and galanin.

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Citations

Jan 1, 1995·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·U WagnerP von Wichert
Apr 22, 2005·Current Allergy and Asthma Reports·Christina NassensteinHarald Renz
Feb 13, 2001·European Journal of Pharmacology·D BredenbrökerU Wagner
Mar 10, 2001·Respiration Physiology·J Widdicombe
Jul 1, 1997·British Journal of Pharmacology·J SchloosC Bruns
Feb 3, 1999·Annals of the New York Academy of Sciences·M PilmaneT P Iismaa
Jun 9, 2006·Journal of Occupational Medicine and Toxicology·Ulrich WagnerDavid A Groneberg
Feb 22, 2008·Journal of Occupational Medicine and Toxicology·Rene SchmidtUlrich Wagner
Nov 29, 2005·European Journal of Pharmacology·Rene SchmidtUlrich Wagner
Feb 7, 2020·Physiological Reports·Luke A Schwerdtfeger, Stuart A Tobet
Aug 4, 1998·Journal of Applied Physiology·T TakebayashiS A Shore
Feb 10, 1998·International Journal of Cancer. Journal International Du Cancer·H IishiA Nakaizumi
Feb 7, 2006·European Journal of Pharmacology·Christina NassensteinArmin Braun

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