Galanin enhances and a galanin antagonist attenuates depression-like behaviour in the rat

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Eugenia KuteevaS O Ogren

Abstract

The effect of intracerebroventricular infusion of galanin and/or the galanin antagonist M35 was studied in the forced swim test. Animals were pre-exposed to water for 15 min 24 h prior to test. Immobility and climbing were assessed during the second, 5 min exposure to water. Rats receiving a single infusion of galanin (3 nmol) displayed a significant increase of immobility. This effect was blocked by co-administration of M35 (1 nmol). M35 alone (1 nmol) produced a significant decrease of immobility. The results further support the hypothesis that galanin may play a role in mood disorders, and that galanin antagonists may represent new candidates for antidepressant treatment.

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Citations

Nov 12, 2013·Neuropeptides·Viktória Kormos, Balázs Gaszner
Jul 1, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Scott DavidsonAlasdair MacKenzie
Jan 4, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eugenia KuteevaSven Ove Ogren
Jan 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Erwan Le MaîtreTomas G M Hökfelt
Mar 4, 2014·Pharmacology, Biochemistry, and Behavior·Penghua FangZhenwen Zhang
May 2, 2014·Proceedings of the National Academy of Sciences of the United States of America·Susanne M BrunnerBarbara Kofler
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