Galanin expression in sympathetic ganglia after partial axotomy is highly localized to those neurons that are axotomized

Neuroscience
A M ShadiackRichard E Zigmond

Abstract

The neuropeptide phenotype of adult sympathetic neurons changes dramatically after postganglionic nerve transection. Studies, thus far, have been done on the superior cervical ganglion; however, one limitation of this preparation is that it is necessary to transect the postganglionic axons quite close to the ganglion. In the present study, we examined the effects of axonal damage on galanin-like immunoreactivity in the middle and inferior cervical ganglion complex. With these ganglia, it is possible to transect postganglionic axons at a considerable distance from their cell bodies and, therefore, to examine the extent to which local tissue damage, rather than specific axonal transection, is required for these changes in neuropeptide phenotype to occur. The anatomy of this system also allowed us to determine the extent to which the changes in galanin expression are restricted to those neurons that have been axotomized. The axons of a small population of the neurons in the middle and inferior cervical ganglia complex project into the cervical sympathetic trunk. Within two days after this trunk was transected, there was an increase in the level of galanin-like immunoreactivity in the complex and in the number of immunostained prin...Continue Reading

References

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Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·M Freidin, J A Kessler
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Jul 2, 1993·Regulatory Peptides·J A KesslerK J Chandross

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Citations

Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·A M ShadiackR E Zigmond
Jul 6, 2004·Neuroscience Letters·Ping Hu, Elspeth M McLachlan
Feb 21, 2006·Neuropeptides·Qi MeiGerald J Taborsky
Jun 25, 2017·Experimental Neurology·Jon P NiemiRichard E Zigmond
Dec 26, 1996·Annals of the New York Academy of Sciences·F SundlerR Uddman

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