PMID: 9184988Jun 23, 1997Paper

Galanin-immunoreactive synaptic terminals on basal forebrain cholinergic neurons in the rat

The Journal of Comparative Neurology
Z Henderson, N Morris

Abstract

Previous studies have indicated that galanin is one of the most abundant peptides in the basal forebrain and that it has a significant modulatory influence on cholinergic transmission. The aim of the present study was to use a light electron microscopic correlation technique to determine whether galanin-immunoreactive terminals form synaptic contacts with basal forebrain cholinergic cells of the rat. Sections from fixed-perfused brains were stained at the light and electron microscopic levels for galanin and choline acetyltransferase immunoreactivity in the same section by using a dual-colour immunohistochemical method. The results showed that galanin-immunoreactive axonal terminals are unevenly distributed in the medial septal nucleus, the diagonal band, and the nucleus basalis. Galanin-positive synapses were most prominent on choline acetyltransferase-positive neurons in the lateral parts of the nucleus of the diagonal band and in the posterior half of the nucleus basalis, which is where there was the greatest overlap between the distribution of galanin-immunoreactive terminals and choline acetyltransferase-positive neurons. The origins of these galanin-positive terminals are not known, but the results confirm that the basal ...Continue Reading

References

Feb 15, 1979·The Journal of Comparative Neurology·C B SaperW M Cowan
Mar 15, 1978·The Journal of Comparative Neurology·J E Krettek, J L Price
Nov 1, 1992·Neuroscience·S O OgrenT Bartfai
May 22, 1992·The Journal of Comparative Neurology·J H KordowerE J Mufson
Jun 5, 1992·Brain Research·B S GivensJ N Crawley
Jan 1, 1991·The Journal of Comparative Neurology·L C WalkerW S Young
Jan 1, 1991·Progress in Neurobiology·N J Woolf
Jun 22, 1986·The Journal of Comparative Neurology·T MelanderA Rökaeus
Nov 15, 1986·The Journal of Comparative Neurology·K Satoh, H C Fibiger
Aug 1, 1987·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·F G WouterloodH W Steinbusch
Oct 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G FisoneT Hökfelt
Nov 15, 1988·The Journal of Comparative Neurology·E A Grove
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J MastropaoloJ N Crawley
Aug 1, 1988·Canadian Journal of Physiology and Pharmacology·T ItoT Kadokawa
Mar 1, 1988·Neuroscience·R P Vertes

❮ Previous
Next ❯

Citations

Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·R A SteinerJ N Crawley
Jul 23, 1999·Annals of the New York Academy of Sciences·L ZaborszkyI Kallo
May 2, 2001·The Journal of Comparative Neurology·S E PérezE J Mufson
Dec 2, 2015·Acta Neuropathologica Communications·Athanasios AlexandrisSteve M Gentleman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Basal Forebrain & Food Avoidance

Neurons in the basal forebrain play specific roles in regulating feeding. Here are the latest discoveries pertaining to the basal forebrain and food avoidance.