Galanin-induced membrane depolarization of neonatal rat cultured dorsal root ganglion cells

European Journal of Pharmacology
R M PuttickG N Woodruff

Abstract

In this study we examined the effects of galanin on membrane currents recorded from neonatal rat cultured dorsal root ganglion neurones using the whole-cell patch-clamp technique. When neurones were voltage-clamped at -60 mV, galanin (1-300 nM) evoked an inward current associated with an increase in input conductance. These effects were observed in 21 of the 33 dorsal root ganglion neurones studied and were not attenuated by the galanin receptor antagonist galantide. Galanin fragments, galanin-(1-16) and galanin-(21-29) (300 nM) also elicited an inward current at -60 mV. The inward current induced by galanin was not linearly related to membrane potential indicating that the membrane current response was the result of more than one ionic event.

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Citations

Nov 8, 2001·European Journal of Pharmacology·Z Wiesenfeld-Hallin, X J Xu
Aug 29, 2000·Brain Research. Developmental Brain Research·K D Phelan, B W Newton
Oct 9, 2002·Trends in Pharmacological Sciences·Hong-Xiang Liu, Tomas Hökfelt
Feb 13, 1999·Progress in Neurobiology·M J Millan
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·Z Q XuT Hökfelt
May 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·Fiona E HolmesDavid Wynick
Aug 30, 2005·Brain Research·Juan Miguel Jimenez-AndradeSusan M Carlton
Jul 20, 2002·Pain·Sarah J L FlattersAnthony H Dickenson
Jul 28, 2004·Pain·Juan Miguel Jimenez-AndradeSusan M Carlton

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