Galanin induces a hyperpolarization of norepinephrine-containing locus coeruleus neurons in the brainstem slice

Neuroscience
V A PieriboneT Hökfelt

Abstract

Galanin applied in the bath or by micropipette directly on to locus coeruleus neurons in an in vitro slice preparation caused a hyperpolarization accompanied by a small decrease in membrane resistance. Immunohistochemical staining of intracellularly filled neurons indicated that the effect of galanin was exerted on norepinephrine neurons of the locus coeruleus. The galanin effect was variable in amplitude and duration and often showed desensitization, with subsequent applications producing a smaller response. When cells were exposed to tetrodotoxin or tetrodotoxin/low calcium media, the galanin response was still present. Under voltage clamp galanin application caused a net outward current that did not reverse in normal potassium concentrations; however, by increasing extracellular potassium concentrations the net outward current was reversed and the reversal potential shifted to a less negative potential. The response to galanin was identical when either KCl or KAc was used as the intracellular electrode solution. Tetraethylammonium chloride significantly reduced or abolished the response to galanin in most cells, although in a few cells the galanin response was not affected. Glibenclamide, a blocker of ATP-sensitive potassium...Continue Reading

References

Jul 31, 1990·Neuroscience Letters·R L Parsons, L M Konopka
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·T BartfaiS Nilsson
Jan 1, 1991·Diabetes·R P RobertsonT F Walseth
May 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H Schmid-AntomarchiM Lazdunski
Jun 22, 1986·The Journal of Comparative Neurology·T MelanderA Rökaeus
May 27, 1986·European Journal of Pharmacology·T MelanderE Brodin
Apr 14, 1987·Biochemical and Biophysical Research Communications·A L ServinM Laburthe
Feb 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J de WeilleM Lazdunski
Apr 13, 1988·European Journal of Pharmacology·E PalazziS Consolo
Apr 15, 1989·European Journal of Biochemistry·G FisoneT Bartfai
May 19, 1989·European Journal of Pharmacology·P DutarR A Nicoll
May 19, 1989·European Journal of Pharmacology·V SeutinA Dresse
Jan 1, 1989·Annals of the New York Academy of Sciences·S F Leibowitz
Dec 15, 1989·Neuroscience Letters·K Krnjević, Y Ben-Ari
Jul 15, 1987·Experientia·T HökfeltT Bartfai
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·H BernardiM Lazdunski
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·U Ungerstedt
Jun 15, 1984·Neuroscience Letters·A RökaeusV Mutt
Sep 1, 1984·Neuroscience·J T WilliamsT M Egan

❮ Previous
Next ❯

Citations

May 27, 2008·Cellular and Molecular Life Sciences : CMLS·S E CountsE J Mufson
Feb 19, 2005·Psychopharmacology·Valeriy SergeyevTomas Hökfelt
Dec 23, 2008·Psychopharmacology·Roopashree NarasimhaiahMarina R Picciotto
Oct 5, 2011·Psychopharmacology·Fiona E HolmesVenetia Zachariou
Sep 22, 1995·Regulatory Peptides·J N Crawley
Jun 15, 1999·Journal of Psychiatric Research·H MurckA Steiger
Apr 2, 2003·Brain Research. Brain Research Reviews·Craig W Berridge, Barry D Waterhouse
Aug 29, 2000·Brain Research. Developmental Brain Research·K D Phelan, B W Newton
Oct 6, 2000·Brain Research. Developmental Brain Research·R WickströmT Hökfelt
Mar 27, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·C C Wrenn, J N Crawley
Oct 25, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jessica J HawesMarina R Picciotto
Jan 4, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Eugenia KuteevaSven Ove Ogren
Nov 9, 2002·Journal of Neurochemistry·Scott E CountsElliott J Mufson
Oct 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sheng XiaZhi-Qing David Xu
Dec 1, 1996·British Journal of Pharmacology·M ConnorM J Christie
Feb 3, 1999·Annals of the New York Academy of Sciences·T HökfeltX Zhang
Feb 3, 1999·Annals of the New York Academy of Sciences·V A PieriboneT Hökfelt
Feb 3, 1999·Annals of the New York Academy of Sciences·Z Q XuT Hökfelt
Jul 20, 2012·Physiological Reviews·Ritchie E BrownRobert W McCarley
Apr 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sheng XiaZhi-Qing David Xu
Jan 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Erwan Le MaîtreTomas G M Hökfelt
Apr 8, 2014·Proceedings of the National Academy of Sciences of the United States of America·Gabriella JuhaszGyorgy Bagdy
Mar 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·R A SteinerJ N Crawley
Mar 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Caroline R Elliott-HuntDavid Wynick
Dec 10, 1999·Proceedings of the National Academy of Sciences of the United States of America·Z Q XuT Hökfelt
Jan 1, 2004·Proceedings of the National Academy of Sciences of the United States of America·Takashi YoshitakeJan Kehr
Jul 18, 2014·Annual Review of Neuroscience·Constance RichterAlexander F Schier
Feb 1, 2007·Journal of Neurochemistry·Caroline R Elliott-HuntDavid Wynick

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.