PMID: 7540270Mar 3, 1995Paper

Galanin is contained in GABAergic neurons in the rat spinal dorsal horn

Neuroscience Letters
D R SimmonsA J Todd

Abstract

In order to determine which types of neuron in laminae I-III of the rat spinal dorsal horn contain the peptide galanin, pre-embedding immunocytochemistry with antiserum to galanin was combined with post-embedding detection of GABA- and glycine-like immunoreactivities. Sixty-eight galanin immunoreactive neurons in laminae I-III selected from four rats were examined, and in each case semi-thin sections through the cell body were tested with a monoclonal antibody to GABA and an antiserum to glycine. All of the 68 galanin-immunoreactive neurons tested were GABA-immunoreactive, while only one of them (in lamina III) was glycine-immunoreactive. This suggests that galanin is contained in inhibitory interneurons, and that (like enkephalin, neuropeptide Y and thyrotropin-releasing hormone) it is mainly restricted to GABAergic neurons which do not use glycine as a co-transmitter.

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Citations

Jul 19, 2006·Cell and Tissue Research·Chiara SalioAdalberto Merighi
Nov 8, 2001·European Journal of Pharmacology·Z Wiesenfeld-Hallin, X J Xu
Oct 9, 2002·Trends in Pharmacological Sciences·Hong-Xiang Liu, Tomas Hökfelt
Apr 12, 2002·Progress in Neurobiology·A Merighi
May 30, 2002·Progress in Neurobiology·Mark J Millan
Feb 13, 1999·Progress in Neurobiology·M J Millan
Apr 13, 2000·The European Journal of Neuroscience·B J KerrS W Thompson
Feb 3, 1999·Annals of the New York Academy of Sciences·Z Wiesenfeld-Hallin, X J Xu
Feb 3, 2012·Physiological Reviews·Hanns Ulrich ZeilhoferGonzalo E Yévenes
Feb 9, 2012·Pain Research and Treatment·Richard P HulseDavid Wynick
Jan 16, 2007·Trends in Pharmacological Sciences·Pablo BrumovskyTomas Hökfelt
Jul 20, 2002·Pain·Sarah J L FlattersAnthony H Dickenson
Mar 21, 2018·Nature Neuroscience·Jing HuangMark A Hoon
Nov 12, 2003·The Journal of Pharmacology and Experimental Therapeutics·Xiao-Ying HuaTony L Yaksh
Aug 13, 2021·The Journal of Comparative Neurology·Camila Oliveira MirandaMiklós Antal

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