Galectin-1 and Galectin-3 and Their Potential Binding Partners in the Dermal Thickening of Keloid Tissues

The American Journal of Dermatopathology
Enrique ArciniegasMarina Chopite

Abstract

Keloids are defined histopathologically as an inflammatory disorder characterized by exhibiting numerous fibroblasts, abnormal vascularization, increased number of proinflammatory immune cells as well as uncontrolled cell proliferation, and exacerbated and disorganized deposition of extracellular matrix (ECM) molecules. Importantly, many of these ECM molecules display N- and O-linked glycan residues and are considered as potential targets for galectin-1 (Gal-1) and galectin-3 (Gal-3). Nevertheless, the presence and localization of Gal-1 and Gal-3 as well as the interactions with some of their binding partners in keloid tissues have not been considered. Here, we show that in the dermal thickening of keloids, versican, syndecan-1, fibronectin, thrombospondin-1, tenascin C, CD44, integrin β1, and N-cadherin were immunolocalized in the elongated fibroblasts that were close to the immune cell infiltrate, attached to collagen bundles, and around the microvasculature and in some immune cells. We also show that Gal-1 and Gal-3 were present in the cytoplasm and along the cell membrane of some fibroblasts and immune and endothelial cells of the dermal thickening. We suggest that Gal-1 and Gal-3, in concert with some of the ECM molecules ...Continue Reading

References

Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R ChammasR R Brentani
Jul 27, 1999·The British Journal of Dermatology·A DalkowskiC C Zouboulis
Jan 4, 2001·Journal of Dermatological Science·M Detmar
Aug 22, 2001·British Journal of Plastic Surgery·D E BoyceK G Harding
Aug 28, 2001·Biochimie·R C Hughes
Mar 5, 2002·The Journal of Investigative Dermatology·Greg SzulgitHumphrey Gardner
Sep 12, 2002·Biochimica Et Biophysica Acta·Fu-Tong LiuJohn L Wang
Sep 24, 2002·Journal of Cell Science·Roumen Pankov, Kenneth M Yamada
Dec 5, 2002·Current Opinion in Structural Biology·C Fred BrewerLinda G Baum
Jan 4, 2003·Nature Reviews. Molecular Cell Biology·Helmut PontaPeter A Herrlich
Jun 17, 2003·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Alice A RobertsLinda G Baum
Oct 11, 2003·Biochemical and Biophysical Research Communications·Elena P MoiseevaNilesh J Samani
Jul 1, 2004·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Kurtis E MoyerH Paul Ehrlich
Jul 28, 2005·Cell Research·Yao Jiong WuBurton B Yang
Dec 24, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Atsushi MasamuneTooru Shimosegawa
Jul 15, 2006·Glycobiology·Isabelle CambyRobert Kiss
Jul 19, 2006·Canadian Journal of Physiology and Pharmacology·Maziar RahmaniBruce M McManus
Jan 16, 2007·FEBS Letters·T Y El SayeghC A McCulloch
May 15, 2007·Cellular and Molecular Life Sciences : CMLS·M T ElolaG A Rabinovich
Jul 20, 2007·Biochemical Society Transactions·A TrebaulK S Midwood
Apr 10, 2008·Journal of Cell Science·Pinak S AcharyaEllen Puré
Jun 14, 2008·Expert Reviews in Molecular Medicine·Ri-Yao YangFu-Tong Liu
Jul 22, 2008·Current Opinion in Cell Biology·Karl E KadlerElizabeth G Canty-Laird
Jan 6, 2009·Nature·Alberto Mantovani
Feb 6, 2009·The Journal of Investigative Dermatology·Paula VelascoBernhard Lange-Asschenfeldt
Jul 15, 2009·Immunological Reviews·Neil C Henderson, Tariq Sethi
Jul 16, 2009·Inflammation & Allergy Drug Targets·Pauline Johnson, Brian Ruffell
Jul 30, 2009·International Journal of Molecular Medicine·Gregor M BranHaneen Sadick
Oct 20, 2009·Journal of Cell Communication and Signaling·Kim S Midwood, Gertraud Orend
Nov 3, 2009·Biochemical and Biophysical Research Communications·Mika IkedaShigehiko Suzuki
Dec 17, 2009·Expert Opinion on Therapeutic Targets·Satoshi Tanaka
Feb 5, 2010·The British Journal of Dermatology·C T OngT T Phan
Feb 12, 2010·Annals of the New York Academy of Sciences·Fu-Tong Liu, Gabriel A Rabinovich
Sep 16, 2010·The FEBS Journal·Tina Manon-JensenJohn R Couchman
Sep 25, 2010·Nature Reviews. Immunology·Lydia Sorokin
Oct 1, 2010·Applied Immunohistochemistry & Molecular Morphology : AIMM·Soad Ali ShakerNahid Hassan Hajrah
Aug 16, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·G P Sidgwick, A Bayat
Oct 29, 2011·Matrix Biology : Journal of the International Society for Matrix Biology·Yvonne Hui-Fang TengPyong Woo Park
Jul 28, 2012·International Journal of Molecular Sciences·Zhenwei ZhangLianghua Wang
Sep 7, 2012·The Journal of Investigative Dermatology·Yosuke YagiAtsushi Utani
Oct 19, 2012·Cell Adhesion & Migration·Wenting Shih, Soichiro Yamada

❮ Previous
Next ❯

Citations

Oct 20, 2020·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Liam D KirkpatrickBonnie C Carney
Jul 6, 2021·Glycobiology·Daniel Giuliano CerriMarcelo Dias-Baruffi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.