Galectin-1 Impairs the Generation of Anti-Parasitic Th1 Cell Responses in the Liver during Experimental Visceral Leishmaniasis

Frontiers in Immunology
Patrick T BunnChristian R Engwerda

Abstract

Many infectious diseases are characterized by the development of immunoregulatory pathways that contribute to pathogen persistence and associated disease symptoms. In diseases caused by intracellular parasites, such as visceral leishmaniasis (VL), various immune modulators have the capacity to negatively impact protective CD4(+) T cell functions. Galectin-1 is widely expressed on immune cells and has previously been shown to suppress inflammatory responses and promote the development of CD4(+) T cells with immunoregulatory characteristics. Here, we investigated the role of galectin-1 in experimental VL caused by infection of C57BL/6 mice with Leishmania donovani. Mice lacking galectin-1 expression exhibited enhanced tissue-specific control of parasite growth in the liver, associated with an augmented Th1 cell response. However, unlike reports in other experimental models, we found little role for galectin-1 in the generation of IL-10-producing Th1 (Tr1) cells, and instead report that galectin-1 suppressed hepatic Th1 cell development. Furthermore, we found relatively early effects of galectin-1 deficiency on parasite growth, suggesting involvement of innate immune cells. However, experiments investigating the impact of galectin...Continue Reading

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Citations

Sep 26, 2020·Frontiers in Immunology·Diyoly AyonaBenoit Desnues
Oct 16, 2018·Frontiers in Immunology·Enrique CorapiDiego Laderach
Oct 14, 2020·PLoS Pathogens·Marcela Montes de OcaChristian R Engwerda
Jul 28, 2021·International Journal of Biological Macromolecules·Baolan WuFang Han
Jul 6, 2021·Growth Factors·Tanja DžopalićBiljana Božić Nedeljković

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Methods Mentioned

BETA
PMA
flow cytometry
transgenic

Software Mentioned

GraphPad Prism
GraphPad

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