Galectin-3, a novel binding partner of beta-catenin

Cancer Research
Tatsuo ShimuraAvraham Raz

Abstract

Galectin-3 (gal-3), a pleiotrophic protein, is an important regulator of tumor metastasis, which like beta-catenin shuttles between the nucleus and the cytosol in a phosphorylation-dependent manner. We report herein that beta-catenin stimulation of cyclin D1 and c-myc expression is gal-3 dependent. Gal-3 binds to beta-catenin/Tcf complex, colocalizes with beta-catenin in the nucleus, and induces the transcriptional activity of Tcf-4 as determined by the TOP/FOPFLASH reporter system. We have identified the beta-catenin-gal-3-binding sequences, which are in the NH2 and COOH termini of the proteins encompassing amino acid residues 1 to 131 and 143 to 250, respectively. These data indicate that gal-3 is a novel binding partner for beta-catenin involved in the regulation of Wnt/beta-catenin signaling pathway.

References

Apr 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M M LotzA M Mercurio
Feb 5, 1998·Biochemical Society Transactions·R C Hughes
Jan 19, 1999·Annual Review of Cell and Developmental Biology·A Wodarz, R Nusse
May 13, 1999·Proceedings of the National Academy of Sciences of the United States of America·M ShtutmanA Ben-Ze'ev
Jan 5, 2000·Cellular Signalling·A Kikuchi
Feb 9, 2000·The Journal of Cell Biology·J HuelskenW Birchmeier
Aug 24, 2000·International Journal of Cancer. Journal International Du Cancer·F A van den BrûleV Castronovo
Jun 19, 2002·Glycobiology·Peter J DavidsonJohn L Wang
Dec 19, 2002·Journal of the National Cancer Institute·Pratima Nangia-MakkerAvraham Raz

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Citations

Dec 16, 2006·Cancer Metastasis Reviews·Vladislav V Glinsky
Mar 29, 2011·Clinical & Experimental Metastasis·Gordana RadosavljevicMiodrag L Lukic
Mar 16, 2012·Immunologic Research·Gordana RadosavljevicMiodrag L Lukic
Jun 14, 2008·Expert Reviews in Molecular Medicine·Ri-Yao YangFu-Tong Liu
Jan 5, 2005·Nature Reviews. Cancer·Fu-Tong Liu, Gabriel A Rabinovich
Nov 8, 2011·Proceedings of the National Academy of Sciences of the United States of America·Linda G Baum
Jun 8, 2012·Pigment Cell & Melanoma Research·Russell R BraeuerMenashe Bar-Eli
Dec 10, 2013·Respiratory Research·Peng GaoPeter G Gibson
Sep 18, 2008·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Junko Nio-KobayashiToshihiko Iwanaga
Mar 4, 2010·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Marcelo HillEduardo Osinaga
Feb 9, 2013·PloS One·Moltira PromkanPimpicha Patmasiriwat
Mar 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·Neil C HendersonTariq Sethi
May 3, 2014·Gene·Xuesong ZhouXiangming Zhang
Mar 25, 2014·Seminars in Cancer Biology·Tatsuyoshi FunasakaPratima Nangia-Makker
Oct 13, 2009·Gastroenterology·Seok-Jun KimKyung-Hee Chun
Nov 15, 2006·Annals of the New York Academy of Sciences·Oliver GimmHenning Dralle
Mar 13, 2008·The Journal of Pathology·P DemetterI Salmon
Oct 11, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ali Akbar EsmailiejahMehdi Moghtadaei
Jul 7, 2015·Laboratory Investigation; a Journal of Technical Methods and Pathology·Nobuko SerizawaJoy X Jiang
Oct 12, 2014·Glycobiology·Giuseppe PuglieseStefano Menini
Aug 13, 2015·Biochimica Et Biophysica Acta·Peter P Ruvolo
Mar 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·U Subrahmanyeswara Rao, Prema S Rao
Feb 16, 2006·Biochimica Et Biophysica Acta·Jerka DumicMirna Flögel
Feb 11, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ming XinXiu-Li Guo
Sep 23, 2014·Experimental and Molecular Pathology·Débora de Oliveira SantosPaulo Rogério de Faria
Apr 6, 2017·Cancer Metastasis Reviews·Xiaoge GaoJunnian Zheng
Jun 15, 2007·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Fabiana H M de MeloRoger Chammas
Nov 22, 2017·International Journal of Molecular Sciences·Carla IacobiniStefano Menini
Dec 8, 2015·Clinical Medicine Insights. Oncology·Hafiz Ahmed, Dina M M AlSadek
Mar 2, 2016·Molecular and Cellular Biology·Monika BambouskovaPetr Draber
Sep 25, 2018·Journal of Cellular and Molecular Medicine·Chang-Shuo HuangKuang-Hui Sun
Apr 13, 2006·Electrophoresis·Jeffrey F KuhnKenneth B Tomer

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