Galectin-3 as a candidate upstream biomarker for quantifying risks of myocardial ageing

ESC Heart Failure
Bryan M H KengAngela S Koh

Abstract

Galectin-3 (Gal-3) is implicated in the pathogenesis of heart failure and is also influenced by ageing. This study aims to determine the extent to which Gal-3 levels estimate odds of myocardial dysfunction in ageing cohorts, 'upstream' prior to clinical disease. Four hundred seventy-five asymptomatic subjects underwent simultaneous assessments of cardiovascular structure and function, with measurements of circulating Gal-3. Myocardial dysfunction was defined as impaired myocardial relaxation (ratio of peak velocity flow in early diastole E (m/s) to peak velocity flow in late diastole by atrial contraction A (m/s) <0.84) (mean E/A ratio 0.84 in the cohort). Of 475 subjects (mean age 68 ± 12 years, 231 women), 222 (47%) had myocardial dysfunction. Subjects with myocardial dysfunction were older (mean age 73 ± 5 vs. 64 ± 14 years, P < 0.0001), and more had hypertension (59 vs. 40%, P < 0.0001), dyslipidaemia (54 vs. 39%, P = 0.001), diabetes mellitus (25 vs. 14%, P = 0.002), higher body mass index (BMI) (24 vs. 23 kg/m2 , P = 0.002), and higher heart rate (76 vs. 71 b.p.m., P = 0.0001). Participants with impaired myocardial relaxation had lower peak velocity flow in early diastole E (0.6 ± 0.1 vs. 0.8 ± 0.2 m/s, P < 0.0001), highe...Continue Reading

References

May 1, 1990·European Heart Journal·E G Lakatta
Aug 6, 1999·Cardiovascular Research·A Nicoletti, J B Michel
Feb 17, 2001·The American Journal of Cardiology·D W KitzmanUNKNOWN Cardiovascular Health Study Research Group
Jan 9, 2003·JAMA : the Journal of the American Medical Association·Margaret M RedfieldRichard J Rodeheffer
Feb 6, 2004·Glycoconjugate Journal·Josiah OchiengPavel Lukyanov
May 7, 2004·The New England Journal of Medicine·Michael R ZileWilliam H Gaasch
Sep 15, 2004·Circulation·Armin Arbab-ZadehBenjamin D Levine
Feb 13, 2007·Journal of the American College of Cardiology·Hans PerssonUNKNOWN Investigators of the CHARM Echocardiographic Substudy-CHARMES
Jun 14, 2008·Expert Reviews in Molecular Medicine·Ri-Yao YangFu-Tong Liu
Dec 23, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Yun-He LiuOscar A Carretero
May 12, 2009·The Medical Clinics of North America·Edward G LakattaSamer S Najjar
Feb 5, 2010·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Dirk J A LokDirk J van Veldhuisen
Feb 12, 2010·American Journal of Public Health·Angelica P HerreraArmin D Weinberg
Sep 3, 2010·Inflammatory Bowel Diseases·Manjula PuthenedamJohn H Kwon
Dec 30, 2010·Annals of Medicine·Rudolf A de BoerDirk J van Veldhuisen
Mar 30, 2011·Archives of Internal Medicine·Antonio CherubiniGary H Mills
Apr 23, 2011·Journal of the American Society of Nephrology : JASN·Kumar SharmaJeffrey B Kopp
Jun 7, 2011·International Journal of Cardiology·Thor UelandLars Gullestad
Aug 24, 2011·Expert Review of Respiratory Medicine·Luca Richeldi, Roland M du Bois
Oct 11, 2011·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Cheng-Hung LeeDelon Wu
Oct 27, 2011·Journal of Internal Medicine·R A de BoerP van der Harst
Sep 4, 2012·Journal of the American College of Cardiology·Jennifer E HoDaniel Levy
Apr 11, 2013·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tar-Choon AwShiow-Pin Tan
Nov 10, 2013·Coronary Artery Disease·James A de Lemos, Christopher R deFilippi
Jan 28, 2014·European Journal of Heart Failure·Luc DjousséJ Michael Gaziano
Jun 26, 2014·Circulation. Arrhythmia and Electrophysiology·Isha AgarwalKenneth J Mukamal
Aug 17, 2014·International Journal of Cardiology·Willibald HochholzerFranz-Josef Neumann
Sep 23, 2014·Journal of the American Heart Association·Wouter C MeijersRudolf A de Boer
Sep 1, 2015·International Journal of Cardiology·Hiroaki KusakaHisao Ogawa
Oct 20, 2015·Clinical Chemistry and Laboratory Medicine : CCLM·Fabian Sanchis-GomarAlejandro Lucia
Apr 3, 2016·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sherif F NaguehAlan D Waggoner
May 15, 2016·Journal of the American Heart Association·John W McEvoyElizabeth Selvin
Oct 5, 2017·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Angela S KohJean-Paul Kovalik

❮ Previous
Next ❯

Citations

Jul 18, 2020·Journal of Clinical Medicine·Klara KomiciErmanno Eleuteri
May 21, 2020·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Alexander E Berezin, Alexander A Berezin
Jun 26, 2021·World Journal of Diabetes·Marko KumricJosko Bozic

❮ Previous
Next ❯

Methods Mentioned

BETA
serum collection

Software Mentioned

STATA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.