Galectin-3 in heart failure with preserved ejection fraction. A RELAX trial substudy (Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart Failure)

JACC. Heart Failure
Omar F AbouEzzeddineMargaret M Redfield

Abstract

This study hypothesized that elevated galectin-3 (Gal-3) levels would identify patients with more advanced heart failure (HF) with preserved ejection fraction (HFpEF) as assessed by key pathophysiological domains. Gal-3 is implicated in the pathogenesis of cardiac fibrosis but is also increased with normal aging and renal dysfunction. Cardiac fibrosis may contribute to cardiac dysfunction, exercise intolerance, and congestion in HFpEF. Two hundred eight patients from the RELAX (Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Diastolic Heart Failure) trial of sildenafil in HFpEF had Gal-3 measured at enrollment. Pathophysiological domains assessed included biomarkers of neurohumoral activation, fibrosis, inflammation and myocardial necrosis, congestion severity and quality of life, cardiac structure and function, and exercise performance. Analysis adjusted for age, sex, and/or cystatin-C levels. Potential interaction between baseline Gal-3 and treatment (sildenafil) effect on the RELAX study primary endpoint (change in peak oxygen consumption) was tested. Gal-3 levels were associated with age and severity of renal dysfunction. Adjusting for age, sex, and/or cystatin-C, Gal-3 was not associated ...Continue Reading

References

Jul 21, 2006·The New England Journal of Medicine·Theophilus E OwanMargaret M Redfield
Sep 19, 2006·Journal of the American College of Cardiology·Roland R van KimmenadeYigal M Pinto
May 28, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Hendrik MiltingFrank Kramer
Aug 4, 2009·European Journal of Heart Failure·Rudolf A de BoerDirk J van Veldhuisen
Dec 30, 2010·Annals of Medicine·Rudolf A de BoerDirk J van Veldhuisen
May 24, 2011·The American Journal of Cardiology·W H Wilson TangAllan L Klein
Jun 7, 2011·International Journal of Cardiology·Thor UelandLars Gullestad
Oct 22, 2011·Circulation. Heart Failure·G Michael FelkerChristopher M O'Connor
Oct 27, 2011·Journal of Internal Medicine·R A de BoerP van der Harst
Sep 4, 2012·Journal of the American College of Cardiology·Jennifer E HoDaniel Levy
Sep 20, 2012·Circulation. Heart Failure·Margaret M RedfieldUNKNOWN Heart Failure Clinical Research Network
Jan 29, 2013·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Gülsüm ErkiletHendrik Milting
Feb 12, 2013·Circulation. Heart Failure·A Rogier van der VeldeRudolf A de Boer
Mar 13, 2013·JAMA : the Journal of the American Medical Association·Margaret M RedfieldUNKNOWN RELAX Trial
Nov 23, 2013·Annals of Transplantation : Quarterly of the Polish Transplantation Society·Andres Beiras-FernandezSimone Kreth
Mar 14, 2014·JACC. Heart Failure·James L Januzzi, G Michael Felker
Jun 16, 2014·JACC. Heart Failure·Tariq AhmadJames L Januzzi

❮ Previous
Next ❯

Citations

Feb 18, 2016·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·C Franssen, A González Miqueo
Apr 22, 2015·International Journal of Cardiology·Vanessa van Empel, Hans-Peter Brunner-La Rocca
Nov 19, 2015·Journal of Molecular and Cellular Cardiology·Margaux A Horn, Andrew W Trafford
Mar 1, 2016·Journal of Cardiac Failure·W H Wilson Tang, Justin L Grodin
Apr 14, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Matteo BeltramiAlberto Palazzuoli
Apr 28, 2016·The Canadian Journal of Cardiology·Adam HarveyRhian M Touyz
Aug 25, 2016·Future Medicinal Chemistry·Katherine B SchuetzeTimothy A McKinsey
Aug 31, 2016·Nature Reviews. Nephrology·Joerg C SchefoldStephan von Haehling
Feb 17, 2017·Current Heart Failure Reports·Vichai SenthongW H Wilson Tang
Jun 6, 2018·Biomarkers in Medicine·Evangelos OikonomouDimitris Tousoulis
Mar 5, 2016·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·W C MeijersR A de Boer
Aug 17, 2018·PloS One·Hilary M DuBrockMargaret M Redfield
Sep 18, 2018·The Journal of International Medical Research·Alexandra StoicaLaurenţiu Şorodoc
Jan 27, 2016·Journal of the American Heart Association·Rohan SamsonThierry H Le Jemtel
Feb 6, 2016·Circulation Research·Anjali Tiku OwensMariell Jessup
Jan 13, 2016·Circulation. Heart Failure·Michael R ZileUNKNOWN Prospective Comparison of ARNI With ARB on Management of Heart Failure With Preserved Ejection Fraction (PARAMOUNT) Investig
Feb 14, 2019·British Journal of Pharmacology·Xiao-Jun DuHelen Kiriazis
Mar 9, 2019·Cardiac Failure Review·Sunil K Nadar, Mohammad Mujtaba Shaikh
Jun 25, 2020·Journal of the American Heart Association·Sri Lekha TummalapalliUNKNOWN CRIC Study Investigators †
Dec 6, 2017·International Journal of Molecular Medicine·Rui DongHui Yuan
Aug 19, 2020·Circulation. Heart Failure·Michael S SabbahMargaret M Redfield
Apr 4, 2018·Annals of Laboratory Medicine·Uzair AnsariIbrahim Akin
May 13, 2017·Heart Failure Reviews·Baris AfsarMehmet Kanbay
Mar 25, 2018·Journal of Clinical Apheresis·Nalu Navarro-AlvarezChristene A Huang
Aug 9, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Marat FudimSalvador Borges-Neto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Cardiac Remodeling

Cardiac remodeling in response to a myocardial infarction is characterized by progressive ventricular dilatation, cardiac hypertrophy, fibrosis, and deterioration of cardiac performance. Discover the latest research on Cardiac Remodeling here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.