Galectin-3 Induces Atrial Fibrosis by Activating the TGF-β1/Smad Pathway in Patients with Atrial Fibrillation.

Cardiology
Minghan XiaoHua Xiao

Abstract

Atrial fibrosis plays a critical role in the occurrence and maintenance of atrial fibrillation. The role of TGF-β1 in mediating atrial fibrosis is well documented. The β-galactoside-binding lectin galectin-3 (Gal-3) is mainly produced by macrophages in biological events such as inflammation and angiogenesis. Previous studies have shown that Gal-3 is associated with atrial fibrosis, but the relationship between TGF-β1 and Gal-3 in atrial fibrosis remains unclear. To determine whether Gal-3 induces atrial fibrosis and atrial fibrillation by activating the TGF-β1/Smad pathway and whether the expression of Gal-3 is mediated by TGF-β1, which can enable assessing the relationship between Gal-3 and TGF-β1 in atrial fibrosis. In this study, 30 patients' right atrial appendages were collected and divided into 3 groups: congenital heart disease sinus rhythm group (n = 10, as a control group), rheumatic heart disease sinus rhythm group (n = 10), and rheumatic heart disease atrial fibrillation group (n = 10). Rat atrial fibroblasts were cultured in vitro, and recombinant Gal-3 and recombinant TGF-β1 proteins were added to the cell culture. The expression of Gal-3, TGF-β1, Smad2, and collagen I was detected by Western blotting and quantitat...Continue Reading

References

Jan 29, 1999·Physiological Reviews·B Swynghedauw
Jul 28, 2004·Cardiovascular Research·Stephan Rosenkranz
Mar 22, 2006·Proceedings of the National Academy of Sciences of the United States of America·Neil C HendersonTariq Sethi
Jan 19, 2008·The American Journal of Pathology·Neil C HendersonTariq Sethi
Feb 26, 2008·Journal of the American College of Cardiology·Brett Burstein, Stanley Nattel
Mar 7, 2008·Cellular and Molecular Life Sciences : CMLS·C-S Lin, C-H Pan
Nov 10, 2010·Journal of Molecular and Cellular Cardiology·Marcin DobaczewskiNikolaos G Frangogiannis
Jan 21, 2011·Physiological Reviews·Ulrich SchottenAndreas Goette
Nov 19, 2011·American Journal of Respiratory and Critical Care Medicine·Alison C MackinnonTariq Sethi
Dec 14, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Joy X JiangNatalie J Török
Mar 3, 2012·PLoS Computational Biology·Trine Krogh-MadsenDavid J Christini
Apr 25, 2013·Cardiovascular Research·Dolkun RahmutulaJeffrey E Olgin
Jan 28, 2014·European Journal of Heart Failure·Luc DjousséJ Michael Gaziano
Mar 13, 2014·Journal of the American College of Cardiology·Stanley Nattel, Masahide Harada
Nov 25, 2014·European Journal of Heart Failure·Frank EdelmannBurkert M Pieske
Feb 17, 2015·Journal of Cardiovascular Electrophysiology·Muhammed U YalcinKudret Aytemir
Apr 30, 2015·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Xiao-Yan WuChang-Sheng Ma
Jan 2, 2016·Journal of the American Heart Association·Matthew NayorJennifer E Ho
Feb 2, 2016·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Xiaobing WangWeimin Li
Aug 16, 2016·Lancet·Jeff S HealeyUNKNOWN RE-LY Atrial Fibrillation Registry and Cohort Study Investigators
Aug 16, 2016·JACC. Basic to Translational Science·Yoshio TakemotoJosé Jalife
Sep 30, 2016·Scientific Reports·Nicolas ClementyDominique Babuty
Jan 13, 2017·Scientific Reports·Diana Hernández-RomeroFrancisco Marín
Mar 25, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Gordon A BeggMuzahir H Tayebjee
May 20, 2017·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Wouter R BergerJoris R de Groot
Sep 12, 2017·The Journal of Clinical Investigation·Hadi KhalilJeffery D Molkentin
Dec 31, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Qi KangZheng Wan
May 29, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Hua ShenZhi-Nong Wang
Nov 15, 2018·Frontiers in Cellular and Infection Microbiology·María F FerrerRicardo M Gómez

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Citations

Jun 26, 2020·Journal of Receptor and Signal Transduction Research·Guohua FuYibo Yu
Dec 15, 2020·Life Sciences·Savalan Babapoor-FarrokhranSumeet K Mainigi
Mar 1, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Alfredo RedondoEzequiel Álvarez
Oct 2, 2021·Acta Biochimica Et Biophysica Sinica·Hechuan WangHua Xiao

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