Galectin-3 Is a Potential Mediator for Atherosclerosis

Journal of Immunology Research
Ziyu GaoLiming Yang

Abstract

Atherosclerosis is a multifactorial chronic inflammatory arterial disease forming the pathological basis of many cardiovascular diseases such as coronary heart disease, heart failure, and stroke. Numerous studies have implicated inflammation as a key player in the initiation and progression of atherosclerosis. Galectin-3 (Gal-3) is a 30 kDa β-galactose, highly conserved and widely distributed intracellularly and extracellularly. Gal-3 has been demonstrated in recent years to be a novel inflammatory factor participating in the process of intravascular inflammation, lipid endocytosis, macrophage activation, cellular proliferation, monocyte chemotaxis, and cell adhesion. This review focuses on the role of Gal-3 in atherosclerosis and the mechanism involved and several classical Gal-3 agonists and antagonists in the current studies.

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Citations

Nov 27, 2020·International Journal of Molecular Sciences·Glória ConceiçãoInês Falcão-Pires
Jan 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhan-Qi CaoPing Leng
Dec 9, 2020·International Journal of Molecular Sciences·Valeria BlandaGiuliana Fortunato
Mar 13, 2021·Therapeutic Advances in Chronic Disease·Gali Epstein ShochetTali Zitman-Gal
Mar 24, 2021·Immunology Letters·Ivan M Srejovic, Miodrag L Lukic
Apr 4, 2021·Journal of Clinical Medicine·Luis M Blanco-ColioJosé Tuñón

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Methods Mentioned

BETA
bronchoalveolar
lavage

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