Galectin-3 mediates survival and apoptosis pathways during Trypanosoma cruzi-host cell interplay

Experimental Parasitology
Michelle de Oliveira ChainLuiz Dione Barbosa De-Melo

Abstract

Neglected tropical diseases, such as Chagas disease caused by the protozoa Trypanosoma cruzi, affect millions of people worldwide but lack effective treatments that are accessible to the entire population, especially patients with the debilitating chronic phase. The recognition of host cells, invasion and its intracellular replicative success are essential stages for progression of the parasite life cycle and the development of Chagas disease. It is predicted that programmed cell death pathways (apoptosis) would be activated in infected cells, either via autocrine secretion or mediated by cytotoxic immune cells. This process should play a key role in resolving infections by hindering the evolutionary success of the parasite. In this research, we performed assays to investigate the role of the lectin galectin-3 (Gal3) in parasite-host signaling pathways. Using cells with endogenous levels of Gal3 compared to Gal3-deficient cells (induced by RNA interference), we demonstrated that T. cruzi mediated the survival pathways and the subverted apoptosis through Gal3 promoting a pro-survival state in infected cells. Infected Gal3-depleted cells showed increased activation of caspase 3 and pro-apoptotic targets, such as poly (ADP-ribose)...Continue Reading

References

Jul 1, 1991·Experimental Parasitology·R L Tarleton
Apr 1, 1989·Memórias do Instituto Oswaldo Cruz·S M De Araújo, E Chiari
Sep 1, 1985·Molecular and Biochemical Parasitology·V T ContrerasS Goldenberg
Mar 15, 1993·Journal of Immunological Methods·R F HussainR T Oliver
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·R Y YangF T Liu
Jul 31, 1999·The Journal of Biological Chemistry·C ScaffidiM E Peter
Nov 29, 2001·The Journal of Biological Chemistry·Tadashi YoshiiAvraham Raz
Jan 10, 2002·Biochemical and Biophysical Research Communications·Corey W TurnerFernando Villalta
Dec 10, 2002·Antioxidants & Redox Signaling·John J LemastersDavid A Brenner
Sep 19, 2003·American Journal of Physiology. Cell Physiology·Maria P AokiSusana Gea
May 20, 2004·Cancer Research·Tomoharu FukumoriAvraham Raz
Sep 18, 2004·Cancer Research·Tatsuo ShimuraAvraham Raz
Sep 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sravanthi Kandula, Clara Abraham
Sep 28, 2004·Journal of Neurochemistry·Marina V Chuenkova, Mercio PereiraPerrin
Oct 27, 2004·Infection and Immunity·Yuliya Y KleshchenkoFernando Villalta
May 4, 2005·Cancer Research·Tatsuo ShimuraAvraham Raz
Jul 29, 2005·The Biochemical Journal·Sujoy BhattacharyaLeonard R Johnson
Feb 16, 2006·Biochimica Et Biophysica Acta·Jerka DumicMirna Flögel
Feb 24, 2007·Journal of Bioenergetics and Biomembranes·Pratima Nangia-MakkerAvraham Raz
May 16, 2007·Molecular Microbiology·John C Carmen, Anthony P Sinai
Jun 5, 2007·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Tomoharu FukumoriAvraham Raz
Jun 5, 2007·Oncogene·G Ceballos-CancinoJ Melendez-Zajgla
Jun 19, 2007·Apoptosis : an International Journal on Programmed Cell Death·Allison M HunterRobert G Korneluk
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alison C MacKinnonTariq Sethi
Jan 31, 2009·Infection and Immunity·Craig Weinkauf, Mercio Pereiraperrin
May 16, 2009·Nature Reviews. Microbiology·Gerardo R Vasta
Jul 15, 2009·Immunological Reviews·Daniel K HsuFu-Tong Liu
Feb 18, 2010·Molecular Cell·Jerry E ChipukDouglas R Green
Oct 29, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sae-Bom JeonEun Jung Park
Dec 24, 2010·Cell Communication and Signaling : CCS·Ganta Vijay ChaitanyaPhanithi Prakash Babu
Feb 26, 2011·Immunological Reviews·L David Sibley
Apr 2, 2011·International Journal of Ayurveda Research·Manish Kumar GoelJugal Kishore
Jan 1, 2010·The Open Parasitology Journal·Tatiana C CardenasFernando Villalta
Sep 29, 2011·Advances in Experimental Medicine and Biology·Gerardo R Vasta

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Sep 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·María Eugenia Giorgi, Rosa M de Lederkremer

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