Galectin-3: presurgical marker of thyroid follicular epithelial cell-derived carcinomas

Journal of Endocrinological Investigation
Enrico SaggioratoFabio Orlandi

Abstract

Preoperative follicular lesion characterisation represents an unsolved diagnostic problem in thyroid nodular disease. Although fine-needle aspiration biopsy is the most reliable preoperative diagnostic procedure, it shows inherent limitations in differentiating adenoma from follicular carcinoma and, sometimes, follicular variants of papillary carcinoma. Galectin-3 cytoplasmic neoexpression has been proposed as a peculiar feature of thyroid malignant cells, easily detectable in cytological and histological samples. The aim of this study was to re-evaluate the galectin-3 expression in a large sample of thyroid lesions using an immunohistocytochemical biotin-free detection system and a specific anti-human-galectin-3 monoclonal antibody in order to avoid the interference of technical factors, a cause of conflicting results recently reported by some authors. We analysed galectin-3 expression of 39 follicular carcinomas, 26 papillary carcinomas, and 105 adenomas in both cell-block samples and their histological counterparts. All cell-block and histological papillary carcinoma samples showed high levels of galectin-3 immunoreactivity. Thirty-four follicular carcinomas were positive, whereas 5 were negative in cell-blocks but positive ...Continue Reading

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Citations

Jan 1, 2008·Biomarker Insights·Rosaria M RuggeriMaria Trovato
Jun 15, 2006·The Journal of Clinical Endocrinology and Metabolism·Young Suk JoMinho Shong
Jul 2, 2015·Expert Review of Proteomics·Fabio PagniFulvio Magni
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Mar 17, 2009·The American Journal of Pathology·Yi WangAvraham Raz
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